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Microdialysis Fraction Collector, FC-90Eicom Syringe PumpsEicom Online Autoinjector, EAS-20SAmuza Rotating Cage Stage, RCS91Eicom HPLC Autosampler “INSIGHT”Eicom HPLC-ECD, HTEC-510

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Microdialysis System Overview

An in vivo microdialysis system collects samples of neurotransmitters, neuropeptides, cytokines, proteins, and metabolites from the brains of freely moving rats or mice at regular intervals. During sample collection, artificial cerebrospinal fluid (aCSF) is delivered to a microdialysis probe that is implanted in the brain of the animal; the fluid that flows back out of the probe is collected and analyzed. Two thin lines of tubing transfer aCSF to and from the microdialysis probe. Since the animal is freely moving, it is common for the lines to become twisted and tangled which increases the risk of the lines detaching. Liquid swivels are often used to prevent twisting of microdialysis lines, but become cumbersome as more lines (tubing, fiber optic, or electrical) are attached to an animal. Our solution is to combat the twisting at the source: the animal that keeps rotating. We do this by placing the animal’s cage on a rotating stage and then we tether the animal to a balance arm that contains a rotation sensor. As the animal rotates, the tether twists the sensor which triggers the stage to counter-rotate. The result is zero net rotations by the animal and therefore no tangles to worry about. Best of all, multiple implants and tubing lines can be kept untwisted.

An ideally constructed in vivo microdialysis system for small molecules includes a syringe pump to deliver artificial cerebrospinal fluid (aCSF) to the implanted microdialysis probe, a cage on a counter-rotating platform, a balance arm containing a rotation sensor to hold the tubing above the animal and prevent line twisting, and a fraction collector to automate sample collection since a series of fractions are usually collected every 5-20 minutes over many hours. A large molecule microdialysis setup, such as AtmosLM, requires a secondary pump to help pull fluid from the probe, for which we place an easy to use peristaltic pump right before the fraction collector.

In addition to the various sampling system components, Eicom also provides HPLC-ECD systems to analyze the samples for neurotransmitters and metabolites.[/vc_column_text][vc_column_text css=”.vc_custom_1446786052430{margin-right: 50px !important;margin-bottom: 50px !important;padding-top: 20px !important;padding-right: 20px !important;padding-bottom: 20px !important;padding-left: 20px !important;background-color: #f5f7f9 !important;}”]

AtmosLM™ Large Molecule (Neuropeptides) Microdialysis System

AtmosLM™ probes feature large pore membranes for better recovery of large molecules including neuropeptides and cytokines. Large molecule recovery with microdialysis technique was challenging, but now… Learn More

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Download CatalogEicom's Microdialysis Catalog Cover

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Advantages of Eicom Microdialysis Products

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Reliable
Eicom has been manufacturing our microdialysis probes for 20 years. All microdialysis probes are functionally inspected before shipping.

Flexible
Custom size microdialysis probes are available even for low volume orders.

Affordable
Competitive price of microdialysis probes improves your bottom line without compromising the quality of microdialysis product.

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