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Pressure Canceling Microdialysis for the recovery of large molecules, neuropeptides, cytokines and proteins.

AtmosLM microdialysis probes feature large pore membranes for better recovery of large molecules including neuropeptides and cytokines. Large molecule recovery with microdialysis technique has always been challenging because the membrane pore size has to be large. This could cause leakage because the pressure in the microdialysis probe is normally comparatively high.

The new Eicom AtmosLM Microdialysis Probes incorporate a vent hole at the head of the probe to equalize the inside pressure with outside atmospheric pressure. (Patented)

Pressure Canceling Technology Used in AtmosLM™

AtmosLM-pressure-canceling-technology

User Reported Detectable Molecules with in Vivo use

  • Amyloid β1-40 (4 kDa)
  • IL-1 β (17 kDa)
  • IL-6 (26 kDa)
  • TNF-α (17 kDa)
  • Tau Protein (>50 kDa)
  • CRF (5 kDa)

(Contact us for detailed conditions.)

Membrane Types

Polyethylene (PE) Membrane with 1,000 kDa Cut Off, 0.44 mm outer diameter.

Variety of Sizes Available for AtmosLM™ Microdialysis Probes

Aside from the Pressure Canceling Technology, the AtmosLM Microdialysis Probe, model PEP, is similar to our AZ microdialysis probes. We carry standard sizes of 4, 8 or 12 mm for the shaft length (X mm) and 1, 2, 3 or 4 mm for the membrane length (Y mm). Other sizes are available.

System Requirements

To collect the sample from the probe, a low-pulse, pull pump is required in addition to the infusion syringe pump. Eicom has developed a new, peristaltic pump, model ERP-10, specifically  for the AtmosLM system. The ERP-10 completes the AtmosLM system offered by Eicom, an incredibly convenient large molecule sampling system. The tubing from syringe to PEP-probes are normally used with 0.1 mm ID JT-10s and WT-35. The tubing from the PEP probe to the ERP-10 need a larger inner diameter of 0.2 mm (JF-10 and WT-35). WT-35 has two tubings inside with 0.1 mm and 0.2 mm ID. Please download the manual for more details