Fast Microdialysis for Serotonin and Dopamine
Eicom can increase the throughput, sensitivity, and temporal resolution of your next microdialysis experiment. Fast microdialysis allows basal level monitoring of dopamine and serotonin in mice with 3 minute online HPLC analyses and 6 minute sampling times. These conditions allow a detection limit for serotonin of 0.8 fMol with an Eicom HTEC-500 HPLC. (Link to publication)
The 6 minute sample time has already proven useful in unmasking physiologically relevant changes in extracellular serotonin levels too fast to examine with standard 20 minute samples. Furthermore, online microdialysis allowed them to troubleshoot microdialysis sampling at the beginning of their experiments instead of after hours of collection.