Publications of Eicom Users

To find a specific word within the publications, please expand all from bottom to top and use the search function of the browser.
Internet Explorer has Find in Edit menu.

HPLC-ECD (Electrochemical Detection)

2018

Cardiac Glutathione Levels Increase in Response to Glucose in Diabetic Rats.
Thorwald, M. A., Godoy-Lugo, J. A., Rodriguez, G. J., Rodriguez, M. A., Jamal, M., Kinoshita, H., … & Ortiz, R. M.
(2018) Free Radical Biology and Medicine.

A Neural Circuit for Gut-Induced Reward.
Han, W., Tellez, L. A., Perkins, M. H., Perez, I. O., Qu, T., Ferreira, J., … & Kaelberer, M. M.
(2018) Cell.

Ropivacaine Protects against Memory Impairment and Hippocampal Damage in a Rat Neurodegeneration Model.
Chiu, K. M., Lin, T. Y., Lee, M. Y., Lu, C. W., Wang, M. J., & Wang, S. J.
(2018) Pharmacology, 102(5-6), 307-315.

Roles of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis in bidirectional brain‐intestine interactions.
Ide, S., Yamamoto, R., Suzuki, H., Takeda, H., & Minami, M.
(2018) Neuropsychopharmacology Reports.

Increased cholinergic response in α-synuclein transgenic mice (h-α-synL62).
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., … & Klein, J.
(2018) ACS Chemical Neuroscience.

Prenatal metformin treatment improves ovarian function in offspring of obese rats.
Álvarez, D., Ceballo, K., Olguín, S., Martinez-Pinto, J., Maliqueo, M., Fernandois, D., … & Cruz, G.
(2018) Journal of Endocrinology, 1(aop).

“SIALYLATION-INCREASING THERAPIES FOR DISEASES ASSOCIATED WITH OXIDATIVE STRESS.”
Huizing, M., Malicdan, M. C., & Carrillo, N.
(2018). U.S. Patent Application No. 15/553,561.
Mesolimbic Dopamine, Its Receptors and Social Learning
Matta, R.
(2018)  (Doctoral dissertation, NOVA Science Publishers).

Central activation of cardiac vagal nerve by α2-adrenergic stimulation is impaired in streptozotocin-induced type 1 diabetic rats.
Kawada, T., Akiyama, T., Sonobe, T., Shimizu, S., Hayama, Y., Pearson, J. T., … & Sugimachi, M.
(2018) Autonomic Neuroscience: Basic and Clinical.

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.
Sobue, A., Kushima, I., Nagai, T., Shan, W., Kohno, T., Aleksic, B., … & Yamamoto, M.
(2018) Scientific Reports, 8(1), 13046.

6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
Urano, Y., Mori, C., Fuji, A., Konno, K., Yamamoto, T., Yashirogi, S., … & Noguchi, N.
(2018) Autophagy, 1-16.

Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.
Mita, Y., Kataoka, Y., Saito, Y., Kashi, T., Hayashi, K., Iwasaki, A., … & Noguchi, N.
(2018) Scientific Reports, 8(1), 12056.

Novel lacto-peptides in fermented dairy products improve memory function and cognitive decline.
Ano, Y., Ayabe, T., Kutsukake, T., Ohya, R., Takaichi, Y., Uchida, S., … & Nakayama, H.
(2018) Neurobiology of Aging.

“Examining the Associative Learning and Accumbal Dopaminergic Mechanisms of Caffeine Reinforcement.”
Bradley, Curtis
(2018) Electronic Theses and Dissertations. Paper 3457. https://dc.etsu.edu/etd/3457

Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol.
Limebeer, C. L., Rock, E. M., Sharkey, K. A., & Parker, L. A.
(2018) eNeuro, ENEURO-0256.

“Neurochemistry, Physiology, and Behavior in a Model of Gulf War Illness”
Macht, V. A.
(2018) Doctoral dissertation, University of South Carolina

“Effort-Related Motivational Dysfunctions: Behavioral and Neurochemical Studies of the Wistar-Kyoto Rat Model of Depression.”
Abbott, Brendan
(2018) Masters Theses. 625.

Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex.
Saiki, M., Matsui, T., Soya, M., Kashibe, T., Shima, T., Shimizu, T., … & Soya, H.
(2018) Scientific reports, 8(1), 10469.

Monoamine system disruption induces functional somatic syndromes associated symptomatology in mice.
Nagakura, Y., Ohsaka, N., Azuma, R., Takahashi, S., Takebayashi, Y., Kawasaki, S., … & Saito, H.
(2018) Physiology & Behavior.

Molecular vibration as a novel explanatory mechanism for the expression of animal colouration.
Galván, I., Cerezo, J., Jorge, A., & Wakamatsu, K.
(2018) Integrative Biology.

Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder.
Kato, T. M., Kubota-Sakashita, M., Fujimori-Tonou, N., Saitow, F., Fuke, S., Masuda, A., … & Kato, T.
(2018) Molecular Psychiatry, 1.

Comparison of brain monoamine content in three populations of Lymnaea that correlates with taste-aversive learning ability.
Aonuma, H., Totani, Y., Sakakibara, M., Lukowiak, K., & Ito, E.
(2018) Biophysics and Physicobiology, 15, 129-135.

Cisplatin increases the number of enterochromaffin cells containing substance P in rat intestine.
Obara, Y., Machida, T., Takano, Y., Shiga, S., Suzuki, A., Hamaue, N., … & Hirafuji, M.
(2018) Naunyn-Schmiedeberg’s archives of pharmacology, 1-12.

Sound‐induced monoaminergic turnover in the auditory forebrain depends on endocrine state in a seasonally‐breeding songbird.
Rodríguez‐Saltos, C. A., Lyons, S. M., Sockman, K. W., & Maney, D. L.
(2018) Journal of Neuroendocrinology.

The Effects of Chronic Amitriptyline on Zebrafish Behavior and Monoamine Neurochemistry.
Meshalkina, D. A., Kysil, E. V., Antonova, K. A., Demin, K. A., Kolesnikova, T. O., Khatsko, S. L., … & Kalueff, A. V.
(2018) Neurochemical Research, 1-9.

Sex Differences in Hippocampal Memory and Kynurenic Acid Formation Following Acute Sleep Deprivation in Rats.
Baratta, A. M., Buck, S. A., Buchla, A. D., Fabian, C. B., Chen, S., Mong, J. A., & Pocivavsek, A.
(2018) Scientific Reports, 8(1), 6963.

TLR4 Inhibits Spinal Gabaergic Activities via Microglial Activation in Chronic Constriction Injury Mice.
Kong, E. L., Wu, X. Z., He, Y., Wang, H. Q., Zhang, Y., Zhang, J. M., … & Wu, F.
(2018) Neuropsychiatry (London), 8(2), 761-771.

Development of a hematocrit-insensitive device to collect accurate volumes of dried blood spots without specialized skills for measuring clozapine and its metabolites as model analytes.
Nakahara, T., Otani, N., Ueno, T., & Hashimoto, K.
(2018) Journal of Chromatography B.

Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity.
Kehr, J., Yoshitake, T., Ichinose, F., Yoshitake, S., Kiss, B., Gyertyán, I., & Adham, N.
(2018) Psychopharmacology, 1-15.

Uptake of plant-derived specific alkaloids allows males of a butterfly to copulate.
Honda, K., Matsumoto, J., Sasaki, K., Tsuruta, Y., & Honda, Y.
(2018) Scientific Reports, 8(1), 5516.

Measurement of 8-hydroxyguanine as an oxidative stress biomarker in saliva by HPLC-ECD.
Kawai, K., Kasai, H., Li, Y. S., Kawasaki, Y., Watanabe, S., Ohta, M., … & Yamato, H.
(2018) Genes and Environment, 40(1), 5.

Mechanisms of the pH-and Oxygen-Dependent Oxidation Activities of Artesunate.
Tsuda, K., Miyamoto, L., Hamano, S., Morimoto, Y., Kangawa, Y., Fukue, C., … & Tamaki, T.
(2018) Biological and Pharmaceutical Bulletin, 41(4), 555-563.

Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with b-amyloid in rats.
Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences, 30, 1e6.

The Effects of Housing Density on Social Interactions and Their Correlations with Serotonin in Rodents and Primates.
Lee, Y. A., Obora, T., Bondonny, L., Toniolo, A., Mivielle, J., Yamaguchi, Y., … & Goto, Y.
(2018) Scientific reports, 8(1), 3497.

Astaxanthin protects against kainic acid-induced seizures and pathological consequences.
Chang, Y., Lu, C. W., Chen, Y. J., Lin, T. Y., Huang, S. K., & Wang, S. J.
(2018) Neurochemistry international.

NF‐κB/p53‐activated inflammatory response involves in diquat‐induced mitochondrial dysfunction and apoptosis.
Choi, S. E., Park, Y. S., & Koh, H. C.
(2018) Environmental Toxicology.

Tyraminergic modulation of agonistic outcomes in crayfish.
Momohara, Y., Aonuma, H., & Nagayama, T.
(2018) Journal of Comparative Physiology A, 1-9.

Peptide YY Causes Apathy-Like Behavior via the Dopamine D2 Receptor in Repeated Water-Immersed Mice.
Yamada, C., Mogami, S., Kanno, H., & Hattori, T.
(2018) Molecular Neurobiology, 1-12.

Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats.
Egashira, N., Akiyoshi, Y., Iba, H., Arai, T., Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences.

Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats.
Kawai, H., Machida, M., Ishibashi, T., Kudo, N., Kawashima, Y., & Mitsumoto, A.
(2018) Biological and Pharmaceutical Bulletin, 41(2), 213-219

Negatively-charged aerosol improves burn wound healing by promoting eNOS-dependent angiogenesis.
Zhao, J., Zhou, F., Chen, L., Shu, B., Zhai, Q., Wu, J., … & Xu, Y.
(2018) Am J Transl Res, 10(1), 246-255.

Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.
Kolata, S. M., Nakao, K., Jeevakumar, V., Farmer-Alroth, E. L., Fujita, Y., Bartley, A. F., … & Martinowich, K.
(2018) Neuropsychopharmacology.

The influence of cellular senescence on intracellular vitamin C transport, accumulation, and function.
Saitoh, Y., Nakawa, A., Tanabe, T., & Akiyama, T.
(2018) Molecular and Cellular Biochemistry, 1-11.

Effects of intravenous tryptophan infusion on thermoregulation in steers exposed to acute heat stress.
Sutoh, M., Kasuya, E., & Yayou, K. I.
(2018) Animal Science Journal.

Malaria infectivity of xanthurenic acid-deficient anopheline mosquitoes produced by TALEN-mediated targeted mutagenesis.
Yamamoto, D. S., Sumitani, M., Hatakeyama, M., & Matsuoka, H.
(2018) Transgenic Research, 1-10.

Night eating model shows time-specific depression-like behavior in the forced swimming test.
Haraguchi, A., Fukuzawa, M., Iwami, S., Nishimura, Y., Motohashi, H., Tahara, Y., & Shibata, S.
(2018)  Scientific Reports, 8(1), 1081.

2017

Effects of 5-HT and insulin on learning and memory formation in food-deprived snails.
Aonuma, H., Totani, Y., Kaneda, M., Nakamura, R., Watanabe, T., Hatakeyama, D., … & Ito, E.
(2017)  Neurobiology of Learning and Memory.

Sexual odor preference and dopamine release in the nucleus accumbens by estrous olfactory cues in sexually naïve and experienced male rats.
Fujiwara, M., & Chiba, A.
(2017)  Physiology & Behavior.

“The role of serotonergic dysfunction in the etiology of affective disorder in a Huntington’s disease translational mouse model.”
Alselehdar, S. K.
(2017)  Doctoral dissertation, Rutgers University-Graduate School-Newark

Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice.
Yu, H., Li, M., Zhou, D., Lv, D., Liao, Q., Lou, Z., … & Zhang, Y.
(2017)  Neuropharmacology.

Generation of dopamine-secreting cells from human adipose tissue-derived stem cells in vitro.
Soheilifar, M. H., Javeri, A., Amini, H., & Taha, M. F.
(2017) Rejuvenation Research, (ja).

Targeting Hypersensitive Corticostriatal Terminals in Restless Legs Syndrome.
Yepes, G., Guitart, X., Rea, W., Newman, A. H., Allen, R. P., Earley, C. J., … & Ferré,
(2017) Annals of Neurology.

Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models.
Misu, H., Nakayama, K., Sotani, K., Inagaki, K., Ikegawa, M., Iwasaki, M., … & Takamura, T.
(2017) Nature Communications, 8(1), 1658.

Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos.
Tanaka, Y., Fujiwara, M., Shindo, A., Yin, G., Kitazawa, T., & Teraoka, H.
(2017) Chemosphere.

5-Hydroxytryptamine-independent antidepressant actions of (R)-ketamine in a chronic social defeat stress model.
Zhang, K., Dong, C., Fujita, Y., Fujita, A., & Hashimoto, K.
(2017) International Journal of Neuropsychopharmacology.

Syntaxin1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Fujiwara, T., Kofuji, T., Mishima, T., & Akagawa, K.
(2017) European Journal of Neuroscience.

Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.
Goeden, N., Notarangelo, F. M., Pocivavsek, A., Beggiato, S., Bonnin, A., & Schwarcz, R.
(2017)  Developmental Neuroscience.

Caste differences in the association between dopamine and reproduction in the bumble bee Bombus ignitus.
Sasaki, K., Matsuyama, H., Morita, N., & Ono, M.
(2017)  Journal of Insect Physiology.

Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson’s disease: Involvement of neuroinflammation and neurotrophins.
Goes, A. T., Jesse, C. R., Antunes, M. S., Ladd, F. V. L., Ladd, A. A. B. L., Luchese, C., … & Boeira, S. P.
(2017) Chemico-Biological Interactions.

Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects.
Sathyasaikumar, K. V., Tararina, M., Wu, H. Q., Neale, S. A., Weisz, F., Salt, T. E., & Schwarcz, R.
(2017) Neuroscience.

Exercise Enhances Medial Septal Cholinergic Function: The Role of Neurotrophins on the Maintenance and Enhancement of the Cholinergic Neuronal Phenotypes
Hall, J. M.
(2017) Doctoral dissertation, State University of New York at Binghamton

L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.
Masukawa, D., Koga, M., Sezaki, A., Nakao, Y., Kamikubo, Y., Hashimoto, T., … & Wakui, H.
(2017) JCI Insight, 2(18).

Striatal N-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice.
Miyamoto, Y., Iegaki, N., Fu, K., Ishikawa, Y., Sumi, K., Azuma, S., … & Nitta, A.
(2017) International Journal of Neuropsychopharmacology.

Microglia may compensate for dopaminergic neuron loss in experimental Parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus
Aono, H., Choudhury, M. E., Higaki, H., Miyanishi, K., Kigami, Y., Fujita, K., … & Nishikawa, N.
(2017) Glia.

Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine‐induced dopamine release in the mouse nucleus accumbens.
Pavon, F. J., Serrano, A., Sidhpura, N., Polis, I., Stouffer, D., Fonseca, F. R., … & Parsons, L. H.
(2017) Addiction Biology.

Cyclic AMP‐regulated opposing and parallel effects of serotonin and dopamine on phototaxis in the Marmorkrebs (marbled crayfish).
Shiratori, C., Suzuki, N., Momohara, Y., Shiraishi, K., Aonuma, H., & Nagayama, T.
(2017) European Journal of Neuroscience.

Noradrenergic modulation of gonadotropin‐inhibitory hormone gene expression in the brain of Japanese quail.
Tobari, Y., Kansaku, N., & Tsutsui, K.
(2017)  Journal of Neuroendocrinology.

Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study.
Takiguchi, K., Uezato, A., Itasaka, M., Atsuta, H., Narushima, K., Yamamoto, N., … & Tamaru, M.
(2017)  BMC psychiatry, 17(1), 249.

Individual differences are consistent across changes in mating status and mediated by biogenic amines.
DiRienzo, N., & Aonuma, H.
(2017)  Behavioral Ecology and Sociobiology, 71(8), 118.

Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring.
Nagano, R., Nagano, M., Nakai, A., Takeshita, T., & Suzuki, H.
(2017)  Neuroscience.

In Vitro Differentiation of Adipose Derived Stem Cells Into Functional Dopaminergic Neurons.
Rad, A. A., Heidari, M. H., Aliaghaei, A., Broujeni, M. E., Shojaei, A., & Abbaszadeh, H. A.
(2017)  Biomedical and Pharmacology Journal, 10(2), 595-605

Metformin increases norepinephrine transporter expression in placenta of patients with polycystic ovary syndrome.
Medina, G., Maliqueo, M., Crisosto, N., Echiburú, B., Sir-Petermann, T., & Lara, H. E.
(2017)  Eur Rev Med Pharmacol Sci, 21(15), 3482-3489

Adolescent Binge Ethanol Exposure Alters Specific Forebrain Cholinergic Cell Populations and Leads to Selective Functional Deficits in the Prefrontal Cortex.
Fernandez, G. M., & Savage, L. M.
(2017)  Neuroscience.

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.
Nakai, N., Nagano, M., Saitow, F., Watanabe, Y., Kawamura, Y., Kawamoto, A., … & Monai, H.
(2017) Science Advances, 3(6), e1603001

Genistein alleviates anxiety-like behaviors in post-traumatic stress disorder model through enhancing serotonergic transmission in the amygdala.
Zhong-Min, W. U., Gui-Lian, N. I., Ai-Min, S. H. A. O., & Rong, C. U. I.
(2017) Psychiatry Research.

Echinacoside ameliorates memory impairment and cholinergic deficit induced by amyloid beta peptide via inhibiting amyloid deposition and toxicology.
Shiao, Y. J., Su, M. H., Lin, H. C., & Wu, C. R.
(2017) Food & Function

LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy.
Ueda, H., & Neyama, H.
(2017) Neurobiology of Pain, 1, 16-25

Effect of basal forebrain stimulation on extracellular acetylcholine release and blood flow in the olfactory bulb.
Uchida, S., & Kagitani, F.
(2017) The Journal of Physiological Sciences, 1-9.

Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism
Oguri, Y., Fujita, Y., Abudukadier, A., Ohashi, A., Goto, T., Furuya, F., … & Hosokawa, M.
(2017) JCI Insight, 2(9).

Differences in activity levels as well as in brain amino acid levels and monoamine metabolisms, that exist between the Djungarian hamster (P. sungorus) and the Roborovskii hamster (P. roborovskii) are scarcely influenced by social isolation.
Ikeda, H., Yamaguchi, T., Kodaira, M., Bahry, M. A., Chowdhury, V. S., & Furuse, M.
(2017) Journal of Pet Animal Nutrition, 20(1), 47-58.

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo.
Shiao, Y. J., Su, M. H., Lin, H. C., & Wu, C. R.
(2017) International Journal of Molecular Sciences, 18(4), 895.

Weak involvement of octopamine in aversive taste learning in a snail.
Aonuma, H., Kaneda, M., Hatakeyama, D., Watanabe, T., Lukowiak, K., & Ito, E.
(2017) Neurobiology of Learning and Memory.

Manipulation of dopamine metabolism contributes to attenuating innate high locomotor activity in ICR mice.
Yamaguchi, T., Nagasawa, M., Ikeda, H., Kodaira, M., Minaminaka, K., Chowdhury, V. S., … & Furuse, M.
(2017) Behavioural Brain Research SreeTestContent1.

Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice.
Fujikawa, R., Higuchi, S., Ikedo, T., Nagata, M., Hayashi, K., Yang, T., … & Minami, M.
(2017) Biochemical and Biophysical Research Communications.

“FOOD ADDITIVE FOR PRODUCING FOOD FOR PREVENTING CRANIAL NERVE DISEASE AND/OR IMPROVING BRAIN FUNCTION.”
Furuya, S., Matsui, T., Tanaka, M., Maebuchi, M., Nakamori, T., & Furuta, H.
(2017) U.S. Patent No. 20,170,049,842. Washington, DC: U.S. Patent and Trademark Office.

Effects of endogenous nitric oxide on adrenergic nerve-mediated vasoconstriction and calcitonin gene-related peptide-containing nerve-mediated vasodilation in pithed rats.
Yamawaki, K., Zamami, Y., Kawasaki, H., & Takatori, S.
(2017) European Journal of Pharmacology.

Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm.
Bellier, J. P., Xie, Y., Farouk, S. M., Sakaue, Y., Tooyama, I., & Kimura, H.
(2017) Brain Structure and Function, 1-19.

Idiopathic Parkinson’s disease patient‐derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains.
Kikuchi, T., Morizane, A., Okita, K., Nakagawa, M., Yamakado, H., Inoue, H., … & Takahashi, J.
(2017) Journal of Neuroscience Research

Oxidative stress inactivates ecto-5′-nucleotidase by inhibiting protein kinase C in rat hearts in vivo.
Obata, T., & Nakashima, M.
(2017) European Journal of Pharmacology

CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.
Hirose, M., Hasegawa, A., Mochida, K., Matoba, S., Hatanaka, Y., Inoue, K., … & Abe, K.
(2017) Scientific Reports, 7, 42476.

Restraint Stress during Pregnancy Rapidly Raises Kynurenic Acid Levels in Mouse Placenta and Fetal Brain.
Notarangelo, F. M., & Schwarcz, R.
(2017) Developmental Neuroscience.

Desipramine increases cardiac parasympathetic activity via α 2-adrenergic mechanism in rats.
Kawada, T., Akiyama, T., Shimizu, S., Fukumitsu, M., Kamiya, A., & Sugimachi, M.
(2017) Autonomic Neuroscience.

Investigation of 5-HT 3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell.
Kojima, S. I., Kojima, K., & Fujita, T.
(2017) European Journal of Pharmacology.

Effects of the 5-HT 6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex.
Mørk, A., Russell, R. V., de Jong, I. E., & Smagin, G.
(2017) European Journal of Pharmacology.

Involvement of host defense mechanisms against Toxoplasma gondii infection in anhedonic and despair-like behaviors in mice.
Mahmoud, M. E., Fereig, R., & Nishikawa, Y.
(2017) Infection and Immunity, IAI-00007.

Key role of the dopamine D4 receptor in the modulation of corticostriatal glutamatergic neurotransmission.
Bonaventura, J., Quiroz, C., Cai, N. S., Rubinstein, M., Tanda, G., & Ferré, S.
(2017) Science Advances, 3(1), e1601631.

Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation.
Tahara, Y., Takatsu, Y., Shiraishi, T., Kikuchi, Y., Yamazaki, M., Motohashi, H., … & Nakamura, T. J.
(2017) npj Aging and Mechanisms of Disease, 3, 16030.

Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy.
Saidan, D., Jianjing, Y., Xueli, H., Leping, L., Jiangnan, H., Zhu, X., & Qichuan, Z.
(2017) Aging and Disease, 0.

2016

Correlated responses in death-feigning behavior, activity, and brain biogenic amine expression in red flour beetle Tribolium castaneum strains selected for walking distance.
Matsumura, K., Sasaki, K., & Miyatake, T.
(2016) Journal of ethology, 34(2), 97-105

Enhanced alcohol-drinking behavior associated with active ghrelinergic and serotoninergic neurons in the lateral hypothalamus and amygdala.
Yoshimoto, K., Nagao, M., Watanabe, Y., Yamaguchi, T., Ueda, S., Kitamura, Y., … & Murakami, K.
(2016) Pharmacology Biochemistry and Behavior.

Discovery of piperonal-converting oxidase involved in the metabolism of a botanical aromatic aldehyde.
Doi, S., Hashimoto, Y., Tomita, C., Kumano, T., & Kobayashi, M.
(2016) Scientific Reports, 6, 38021.

Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice.
Kubo, H., Hoshi, M., Mouri, A., Tashita, C., Yamamoto, Y., Nabeshima, T., & Saito, K.
(2016) Immunology Letters.

Vitamin C impacts anxiety-like behavior and stress-induced anorexia relative to social environment in SMP30/GNL knockout mice.
Koizumi, M., Kondo, Y., Isaka, A., Ishigami, A., & Suzuki, E.
(2016) Nutrition Research.

Identification of 1-Methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethoxy) phenyl] pyridin-4-yl} methyl)-1H-imidazole-4-carboxamide as a Potent and Orally Available Glycine Transporter 1 Inhibitor.
Yamamoto, S., Ohta, H., Abe, K., Kambe, D., Tsukiyama, N., Kawakita, Y., … & Yasuhara, A.
(2016) Chemical and Pharmaceutical Bulletin, 64(11), 1630-1640

Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion.
Du, C. K., Zhan, D. Y., Akiyama, T., Inagaki, T., Shishido, T., Shirai, M., & Pearson, J. T.
(2016) American Journal of Physiology-Heart and Circulatory Physiology, ajpheart-00471.

Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
Ishikawa, T., Imamura, K., Kondo, T., Koshiba, Y., Hara, S., Ichinose, H., … & Takahashi, R.
(2016) Human Molecular Genetics, ddw339.

Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1.
Samata, B., Doi, D., Nishimura, K., Kikuchi, T., Watanabe, A., Sakamoto, Y., … & Takahashi, J.
(2016) Nature Communications, 7, 13097.

Long-Term Citalopram Treatment Alters the Stress Responses of the Cortical Dopamine and Noradrenaline Systems: the Role of Cortical 5-HT.
Hanada, Y., Yamada, M., Kakuma, T., Kawahara, H., & Nishi, A.
(2016) International Journal of Neuropsychopharmacology, 19(8), 1-12.

Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Tashiro, T., Murakami, Y., Mouri, A., Imamura, Y., Nabeshima, T., Yamamoto, Y., & Saito, K.
(2016) Behavioural Brain Research SreeTestContent1.

In utero exposure to diesel exhaust particles induces anxiogenic effects on male offspring via chronic activation of serotonergic neuron in dorsal raphe nucleus.
Yokota, S., Oshio, S., & Takeda, K.
(2016) The Journal of Toxicological Sciences, 41(5), 583-593.

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway.
Zhang, W., He, H., Song, H., Zhao, J., Li, T., Wu, L., … & Chen, J.
(2016) Parkinson’s Disease, 2016.

Esterification of 24 (S)-hydroxycholesterol induces formation of atypical lipid droplet-like structures, leading to neuronal cell death.
Takabe, W., Urano, Y., Vo, D. K. H., Shibuya, K., Tanno, M., Kitagishi, H., … & Noguchi, N.
(2016) Journal of Lipid Research, jlr-M068775.

The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD).
Ebenezer, P. J., Wilson, C. B., Wilson, L. D., Nair, A. R., & Francis, J.
(2016) PloS one, 11(9), e0160923.

Role of rho-mediated ROCK-Semaphorin3A signaling pathway in the pathogenesis of Parkinson’s disease in a mouse model.
Qi, L., Tang, Y. G., Wang, L., He, W., Pan, H. H., Nie, R. R., & Can, Y.
(2016) Journal of the Neurological Sciences.

Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.
Ishizu, N., Yui, D., Hebisawa, A., Aizawa, H., Cui, W., Fujita, Y., … & Watase, K.
(2016) Human Molecular Genetics, ddw279.

“PHARMACOLOGICAL IMPLICATIONS OF ADENOSINE 2A RECEPTOR-DOPAMINE TYPE 2 RECEPTOR HETEROMERIZATION.”
Compass, V. S.
(2016)

Dopaminergic abnormalities in Hdac6-deficient mice.
Fukada, M., Nakayama, A., Mamiya, T., Yao, T. P., & Kawaguchi, Y.
(2016) Neuropharmacology

“Color measurement of the animal integument predicts the content of specific melanin forms.”
Galván, Ismael, and Kazumasa Wakamatsu.
(2016) RSC Advances

“Neuroprotective Effects of Salidroside in the MPTP mouse model of Parkinson’s.”
Zhang, X., & Chen, J.

Acute arterial baroreflex‐mediated changes in plasma catecholamine concentrations in a chronic rat model of myocardial infarction.
Kawada, T., Akiyama, T., Li, M., Zheng, C., Turner, M. J., Shirai, M., & Sugimachi, M.
(2016) Physiological Reports, 4(15), e12880.

Toxoplasma gondii Infection in Mice Impairs Long-Term Fear Memory Consolidation Through Dysfunction of the Cortex and Amygdala.
Ihara, F., Nishimura, M., Muroi, Y., Mahmoud, M. E., Yokoyama, N., Nagamune, K., & Nishikawa, Y.
(2016) Infection and Immunity, IAI-00217.

3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of l-DOPA.
Asanuma, M., & Miyazaki, I.
(2016) BMC Neuroscience, 17(1), 1.

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2, 3-dioxygenase 1.
Murakami, Y., Ishibashi, T., Tomita, E., Imamura, Y., Tashiro, T., Watcharanurak, K., … & Fujigaki, H.
(2016) Scientific Reports, 6, 29920.

In vivo neurochemical evidence that delta1-, delta2-and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats.
Kiguchi, Y., Aono, Y., Watanabe, Y., Yamamoto, S., Shimizu, K., Shimizu, T., … & Saigusa, T.
(2016) European Journal of Pharmacology.

Neurochemical Substrates of Asymmetrical Sleep in the Fur Seal.
Lapierre, J. L.
(2016) Doctoral dissertation, University of Toronto.

Carbonyl stress-induced 5-hydroxytriptamine secretion from RIN-14B, rat pancreatic islet tumor cells, via the activation of transient receptor potential ankyrin 1.
Suzawa, S., Takahashi, K., Shimada, T., & Ohta, T.
(2016) Brain Research Bulletin.

“METHOD FOR PRODUCING DOPAMINERGIC NEURONS.”
Shoji, M.
(2016) U.S. Patent No. 20,160,177,260. Washington, DC: U.S. Patent and Trademark Office.

Involvement of glutamatergic N-Methyl-D-Aspartate receptors in the expression of increased head-dipping behaviors in the hole-board tests of olfactory bulbectomized mice.
Hirose, N., Saitoh, A., & Kamei, J.
(2016) Brain Research.

Dopamine level in the stratium exhibits circadian rhythms in the rat model of Tourette syndrome.
Ji, X., Wu, M., & Zhang, X.
(2016) Int J Clin Exp Med, 9(6), 9015-9020.

Progressive loss of nigrostriatal dopaminergic neurons induced by inflammatory responses to fipronil.
Park, J. H., Park, Y. S., & Koh, H. C.
(2016) Toxicology Letters.

Maternal Inflammation Disrupts Fetal Neurodevelopment via Increased Placental Output of Serotonin to the Fetal Brain.
Goeden, N., Velasquez, J., Arnold, K. A., Chan, Y., Lund, B. T., Anderson, G. M., & Bonnin, A.
(2016) The Journal of Neuroscience, 36(22), 6041-6049.

Octopaminergic system in the central nervous system of the terrestrial slug Limax.
Matsuo, R., Tanaka, M., Fukata, R., Kobayashi, S., Aonuma, H., & Matsuo, Y.
(2016) Journal of Comparative Neurology.

New Insights on Different Response of MDMA-Elicited Serotonin Syndrome to Systemic and Intracranial Administrations in the Rat Brain.
Shokry, I. M., Callanan, J. J., Sousa, J., & Tao, R.
(2016) PloS one, 11(5), e0155551.

Tyraminergic and Octopaminergic Modulation of Defensive Behavior in Termite Soldier.
Ishikawa, Y., Aonuma, H., Sasaki, K., & Miura, T.
(2016) PloS one, 11(5), e0154230.

“Acute and Chronic Effects of Inhalants in Intracranial Self-stimulation.”
Tracy, Matthew.
(2016)

Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats.
Lin, T. Y., Lu, C. W., & Wang, S. J.
(2016) NeuroToxicology.

The Rapidly-Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits.
Witkin, J. M., Monn, J. A., Schoepp, D. D., Li, X., Overshiner, C. D., Mitchell, S. N., … & Rorick-Kehn, L. M.
(2016) Journal of Pharmacology and Experimental Therapeutics, jpet-116.

“Original Research Article Effects of intravenous cariporide on norepinephrine and myoglobin releases during myocardial ischemia/reperfusion in rabbits.”
Shigeru Sakurai, M. D., Kuroko, Y., Kawada, T., Sugimachi, M., & Shuji Shimizu, M. D.

Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase.
Otsuki, N., Homma, T., Fujiwara, H., Kaneko, K., Hozumi, Y., Shichiri, M., … & Yoshida, Y.
(2016)  Regulatory Toxicology and Pharmacology.

Vitamin D3: a role in dopamine circuit regulation, diet-induced obesity, and drug consumption.
Trinko, J. R., Land, B. B., Solecki, W. B., Wickham, R. J., Tellez, L. A., Maldonado-Aviles, J., … & DiLeone, R. J.
(2016)  eneuro, ENEURO-0122.

Stability of Adrenaline in Irrigating Solution for Intraocular Surgery.
Shibata, Y., Kimura, Y., Taogoshi, T., Matsuo, H., & Kihira, K.
(2016)  Biological and Pharmaceutical Bulletin, 39(5), 879-882.

Environmental Estrogen-like Substances Enhances 1-Methyl-4-Phenylpyridinium Ion-Induced Hydroxyl Radical Generation in Rat Striatum.
Obata, T.
(2016)  MJ Anest, 1(1), 001.

Prenatal phencyclidine treatment induces behavioral deficits through impairment of GABAergic interneurons in the prefrontal cortex.
Toriumi, K., Oki, M., Muto, E., Tanaka, J., Mouri, A., Mamiya, T., … & Nabeshima, T.
(2016)  Psychopharmacology, 1-9.

Synthesis of 24 (S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.
Shibuya, K., Watanabe, T., Urano, Y., Takabe, W., Noguchi, N., & Kitagishi, H.
(2016)  Bioorganic & Medicinal Chemistry.

Opening of ATP-sensitive K+(K ATP) channels enhance hydroxyl radical generation induced by MPP+ in rat striatum.
Obata, T., & Nakashima, M.
(2016)  Journal of the Neurological Sciences.

Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation: An in vivo microdialysis study.
Kitta, T., Mitsui, T., Kanno, Y., Chiba, H., Moriya, K., Yoshioka, M., & Shinohara, N.
(2016)  International Journal of Urology.

Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse.
Wu, H. H., Choi, S., & Levitt, P.
(2016)  Placenta.

Changes of brain monoamine levels and physiological indexes during heat acclimation in rats.
Nakagawa, H., Matsumura, T., Suzuki, K., Ninomiya, C., & Ishiwata, T.
(2016)  Journal of Thermal Biology.

Changes in neurotransmitter levels and expression of immediate early genes in brain of mice infected with Neospora caninum.
Ihara, F., Nishimura, M., Muroi, Y., Furuoka, H., Yokoyama, N., & Nishikawa, Y.
(2016)  Scientific Reports, 6.

Monoamine oxidase-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia–reperfusion in rats.
Inagaki, T., Akiyama, T., Du, C. K., Zhan, D. Y., Yoshimoto, M., & Shirai, M.
(2016) Free Radical Research, (just-accepted), 1-32.

Artificially reared mice exhibit anxiety-like behavior in adulthood.
YASUDA, H., HARAUMA, A., KATO, M., OOTOMO, Y., HATANAKA, E., & MORIGUCHI, T.
(2016) Experimental Animals, (0).

Social Isolation-Induced Territorial Aggression in Male Offspring Is Enhanced by Exposure to Diesel Exhaust during Pregnancy.
Yokota, S., Oshio, S., Moriya, N., & Takeda, K.
(2016)  PLOS ONE, 11(2), e0149737.

The influence of n-3 fatty acids on maternal behavior and brain monoamines in the perinatal period.
Harauma, A., Sagisaka, T., Horii, T., Watanabe, Y., & Moriguchi, T.
(2016)  Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA).

Dopamine regulates termite soldier differentiation through trophallactic behaviours.
Yaguchi, H., Inoue, T., Sasaki, K., & Maekawa, K
(2016)  Royal Society Open Science, 3(2), 150574.

The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem.
Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T., & Furuya, S.
(2016)  International Journal of Peptides, 2016.

“Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior.”
Hall, J. M., & Savage, L. M.
(2016)  Experimental Neurology.

“Research Article The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem.”
Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T., & Furuya

Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors
Tamano, R., Ishida, M., Asaki, T., Hasegawa, M., & Shinohara, S.
(2016)  Neuroscience Letters.

Effects of soybean ingestion on pharmacokinetics of levodopa and motor symptoms of Parkinson’s disease—In relation to the effects of Mucuna pruriens.
Nagashima, Y., Kondo, T., Sakata, M., Koh, J., & Ito, H.
(2016)  Journal of the Neurological Sciences.

Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT.
Ishida, Y., Ebihara, K., Tabuchi, M., Imamura, S., Sekiguchi, K., Mizoguchi, K., … & Ikarashi, Y.
(2016) Biological and Pharmaceutical Bulletin, 39(1), 104-113.

A Stress-related Peptide Bombesin Centrally Induces Frequent Urination through Brain Bombesin Receptor Types 1 and 2 in the Rat.
Shimizu, T., Shimizu, S., Higashi, Y., Nakamura, K., Yoshimura, N., & Saito, M.
(2016) Journal of Pharmacology and Experimental Therapeutics, jpet-115.

2015

Studies on Natural Low Molecular Mass Organic Compounds with Catalytic Activity.
触媒活性を有する低分子天然有機化合物に関する研究
(2015) Doctoral dissertation, School of Life and Environmental Sciences, University of Tsukuba.

“ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER’S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAME.”
Goshima, Y., Nakamura, F., Yamashita, N., Seo, H., Hashimoto, S., Murakami, K., … & Sasakura, Y.
(2015)  U.S. Patent No. 20,150,368,327. Washington, DC: U.S. Patent and Trademark Office.

A 5‐HT2A/2C receptor agonist, 1‐(2, 5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane, mitigates developmental neurotoxicity of ethanol to serotonergic neurons.
Ishiguro, T., Sakata‐Haga, H., & Fukui, Y.
(2015) Congenital anomalies.

“MARKER FOR DEPRESSION, ASSAY METHOD, METHOD FOR DETERMINING DEPRESSION, SCREENING METHOD FOR ANTIDEPRESSANTS, AND KIT.”
Nabeshima, T., Mouri, A., & Noda, Y.
(2015) U.S. Patent No. 20,150,355,204. Washington, DC: U.S. Patent and Trademark Office.

Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium.
Obata, T., & Nakashima, M.
(2015) European Journal of Pharmacology.

Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress.
Kato-Kataoka, A., Nishida, K., Takada, M., Suda, K., Kawai, M., Shimizu, K., … & Miyazaki, K.
(2015) Beneficial Microbes, 1-12.

Sex-and SERT-Mediated Differences in Stimulated Serotonin Revealed by Fast Microdialysis.
Yang, H., Sampson, M. M., Senturk, D., & Andrews, A. M.
(2015) ACS Chemical Neuroscience.

Insular neural system controls decision-making in healthy and methamphetamine-treated rats.
Mizoguchi, H., Katahira, K., Inutsuka, A., Fukumoto, K., Nakamura, A., Wang, T., … & Yamada, K.
(2015) Proceedings of the National Academy of Sciences, 201418014.

Rab3 interacting molecule 3 mutations associated with autism alter regulation of voltage-dependent Ca 2+ channels.
Takada, Y., Hirano, M., Kiyonaka, S., Ueda, Y., Yamaguchi, K., Nakahara, K., … & Mori, Y.
(2015) Cell Calcium.

Chewing, Stress-Related Diseases, and Brain Function.
Kubo, K. Y., Chen, H., Liu, J. H., Zhou, X., & Darbin, O.
(2015) BioMed Research International, 2015.

Changes in free amino acid and monoamine concentrations in the chick brain associated with feeding behavior.
Tran, P. V., Chowdhury, V. S., Nagasawa, M., & Furuse, M.
(2015) SpringerPlus 4(1), 252.

Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex.
Ueda, S., Niwa, M., Hioki, H., Sohn, J., Kaneko, T., Sawa, A., & Sakurai, T.
(2015). Molecular Neuropsychiatry,1(2), 94-104.

GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.
Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., … & Contet, C.
(2015) Proceedings of the National Academy of Sciences, 201416146.

Nicotinic receptor-dependent and-independent effects of galantamine, an acetylcholinesterase inhibitor, on the non-neuronal acetylcholine system in C2C12 cells.
Oikawa, S., Mano, A., Iketani, M., & Kakinuma, Y.
(2015). International Immunopharmacology.

Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice.
Hwa, L. S., Nathanson, A. J., Shimamoto, A., Tayeh, J. K., Wilens, A. R., Holly, E. N., … & Miczek, K. A.
(2015). Psychopharmacology,1-14.

Reded prefrontal dopaminergic activity in valproic acid-treated mouse autism model.
Hara, Y., Takuma, K., Takano, E., Katashiba, K., Taruta, A., Higashino, K., … & Matsuda, T.
(2015). Behavioural Brain Research.

2013

Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis.
Yang, H., Thompson, A. B., McIntosh, B. J., Altieri, S. C., & Andrews, A. M.
(2013). ACS chemical neuroscience, 4(5), 790-798.

Relief of hypersensivitity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80

2012

Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve insury.
Hayashida K, Kimura M, Yoshizumi M,  Hobo S, Obata H, J Eisenach
(2012) Anesthesiology,  117;389-98

Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Yoshizumi M, Parker R, Esenach J, Hayashida K.
(2012) Anesthesiology 116:1347-53

2011

The roles of vesicular GABA transporter during embryonic development.
斉藤憲史, & サイトウ,ケンジ.
(2011) application/pdf.

2009

[16-1]
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
(2009) Brain Research 1260; 30-37

2008

[16-3]
Dopamine Release in the Ventromedial Hypothalamus of Growing Chickens Decreases when They are Fed a Lysine Devoid Diet
Ichijo A, Hayashi N, Fukuoka C, Hu JJ, Yoshizawa F, Sugahara K
(2008) The Journal of Poultry Science 45(4);281-286

[15-16]
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Mitsushima D, Takase K, Funabashi T, Kimura F
(2008) Endocrinology;149(2):802-811. Epub 2007 Oct 25

[15-21]
Identification of glutamic acid decarboxylase gene and distribution of GABAergic nervous system in the planarian Dugesia japonica.
Nishimura K, Kitamura Y, Umesono Y, Takeuchi K, Takata K, Taniguchi T, Agata K
Neuroscience; 153(4):1103-1114. Epub 2008 Mar 22.

[15-24]
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M
(2008) Journal of Neuroscience; 28(31):7728-7736

[15-33]
Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
(2008) Toxicology and applied pharmacology Jan 15;226(2):192-198

2007

[15-3]
Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats.
Takase K, Mitsushima D, Funabashi T, Kimura F
(2007) Brain Research 1154:105-115. Epub 2007 Apr 5

[15-6]
Protein S-guanylation by the biological signal 8-nitroguanosine 3’,5’-cyclic monophosphate.
Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T
(2007) Nature Chemical Biology. Nov;3(11):727-735. Epub 2007 Sep 30.

[15-7]
Kynurenic acid leads, dopamine follows: a new case of volume transmission in the brain?
Wu HQ, Rassoulpour A, Schwarcz R
(2007) Journal of Neural Transmission 114(1):33-41. Epub 2006 Aug 24.

[14-24]
Disposition of protein-bound 3-nitrotyrosine in rat plasma analysed by a novel protocol for HPLC-ECD.
Hitomi YH, Okuda J, Nishino H, Kambayashi Y, Hibino Y, Takemoto K, Takigawa T, Ohno H, Taniguchi N, Ogino K
(2007) Journal of Biochemistry (Tokyo) 141(4):495-502. Epub 2007 Jan 29

[14-27]
Effect of lipid-hydroperoxide-induced oxidative stress on vitamin E, ascorbate and glutathione in the rabbit retina.
Kamegawa M, Nakanishi-Ueda T, Iwai S, Ueda T, Kosuge S, Ogura H, Sasuga K, Inagaki M, Watanabe M, Oguchi K, Yasuhara H, Armstrong D, Koide R
(2007) Ophthalmic Research 39(1):49-54. Epub 2006 Dec 11

[15-18]
Antidepressant administration modulates neural stem cell survival and serotoninergic differentiation through bcl-2.
Chen SJ, Kao CL, Chang YL, Yen CJ, Shui JW, Chien CS, Chen IL, Tsai TH, Ku HH, Chiou SH
(2007) Current Neurovascular Research; 4(1):19-29

[15-22]
Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.
Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M
(2007) Regulatory Toxicology and Pharmacology; 47(1):19-28. Epub 2006 Aug 21.

[15-31]
Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase.
Haramaki N, Ikeda H, Takenaka K, Katoh A, Sugano R, Yamagishi S, Matsuoka H, Imaizumi T
(2007) Arteriosclerosis, Thrombosis, and Vascular Biology 27(6):1471-147.

2006

[14-1]
Ascorbic acid concentration in rabbit vitreous measured by microdialysis with HPLC-electrochemical detection before and after vitreous surgery.
Koide K, Zhang XM, Ohishi K, Usami Y, Hotta Y, Hiramitsu T
(2006) Experimental Eye Research 82(5):868-873

[14-4]
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
(2006) Anesthesiology 104(5):1023-1032

[14-5]
Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats.
Sasaki M, Obata H, Kawahara K, Saito S, Goto F
(2006) Pain 122(1-2):130-136

[15-2]
Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum.
Kawasaki T, Ishihara K, Ago Y, Nakamura S, Itoh S, Baba A, Matsuda T
(2006) European Journal of Pharmacology 542(1-3):92-99. Epub 2006 May 17

[15-5]
Up-regulation of microglial CD11b expression by nitric oxide.
Roy A, Fung YK, Liu X, Pahan K
(2006) The Journal of Biological Chemistry 281(21):14971-1480. Epub 2006 Mar 20

[13-29]
Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
Dong HL, Fukuda S, Murata E, Higuchi T
(2006) Anesthesiology 104(1):122-133

[13-31]
Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions.
De Leonibus E, Verheij MM, Mele A, Cools A
(2006) European Journal of Neuroscience 23(5):1332-1340

[13-32]
The effects of blood feeding and exogenous supply of tryptophan on the quantities of xanthurenic acid in the salivary glands of Anopheles stephensi (Diptera: Culicidae).
Okech B, Arai M, Matsuoka H
(2006) Biochemical and Biophysical Research Communication 341(4):1113-1118

[14-11]
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T
(2006) Journal of Neuroscience 26(2):398-405

[14-20]
Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity.
Takahashi R, Oda Y, Tanaka K, Morishima HO, Inoue K, Asada A
(2006) Anesthesiology 105(5):984-989

[14-32]
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats.
Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F|
(2006) European Journal of Neuroscience 24(11):3245-3254

[15-28]
Detection of Genotoxic Nucleosides, 8-Hydroxydeoxyguanosine, 8-Hydroxyguanosine and Free Base 8-Hydroxyguanine, in Fish Food Products.
Kawai K, Svoboda P, Kasai H
(2006) Genes and Environment 28(3) 120-122

2005

[12-12]
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice.
Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S
(2005) Proceedings of the National Academy of Sciences USA (PNAS) 102: 4170-4175

[12-18]
Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.
Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I
(2005) Brain Research 1039(1-2):90-96

[12-20]
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.
Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N
(2005) The Journal of Clinical Investigation 115: 102-109

[12-21]
Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers.
Morita H, Ikeda H, Haramaki N, Eguchi H, Imaizumi T
(2005) Journal of the American College of Cardiology 45: 589-594

[12-22]
A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats.
Kamiya Y, Ohta Y, Imai Y, Arisawa T, Nakano H
(2005) World Journal of Gastroenterology 11: 1324-1332

[13-14]
Expression of acetylcholine (ACh) and ACh-synthesizing activity in Archaea.
Yamada T, Fujii T, Kanai T, Amo T, Imanaka T, Nishimasu H, Wakagi T, Shoun H, Kamekura M, Kamagata Y, Kato T, Kawashima K
(2005) Life Sciences 77: 1935-1944

[13-16]
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136: 593-599

[13-17]
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats.
Masuda J, Mitsushima D, Funabashi T, Kimura F
(2005) Neuroscience 132: 537-542

[13-21]
Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study.
Yamamoto T, Sakakibara R, Hashimoto K, Nakazawa K, Uchiyama T, Liu Z, Ito T, Hattori T.
(2005) Neuroscience 135: 299-303

[14-18]
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M
(2005) British Journal of Pharmacology 145(8):1035-1044

[14-29]
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136(2):593-9. Epub 2005 Oct 13

2004

[12-7]
Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
Yamato T, Misumi Y, Yamasaki S, Kino M, Aomine M
(2004) Diabetes, Nutrition & Metabolism 17: 128-136

[14-8]
Brain microdialysis study of the effects of hazardous chemicals on the central nervous system 2. Toluene exposure and cerebral acetylcholine.
Honma T, Suda M
(2004) Industrial Health 42(3):336-347

[11-20]
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73

[12-23]
Serotonin modifies the sensitivity of the male silkmoth to pheromone.
Gatellier L, Nagao T, Kanzaki R
(2004) The Journal of Experimental Biology. 207: 2487-2496

[12-24]
Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL.
Shim JW, Koh HC, Chang MY, Roh E, Choi CY, Oh YJ, Son H, Lee YS, Studer L, Lee SH
(2004) Journal of Neuroscience 24: 843-852

[12-25]
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Okamura N, Hashimoto K, Shimizu E, Kumakiri C, Komatsu N, Iyo M
(2004) Neuropsychopharmacology 29: 544-550

[12-28]
7Alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.
Matsunaga M, Ukena K, Baulieu EE, Tsutsui K
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 17282-17287

[13-12]
Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J
(2004)British Journal of Pharmacology 142: 414-418

[13-28]
Sexual dimorphism of GABA release in the medial preoptic area and luteinizing hormone release in gonadectomized estrogen-primed rats.
Tin-Tin-Win-Shwe, Mitsushima D, Shinohara K, Kimura F
(2004) Neuroscience 127(1):243-250

[14-21]
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Shen HW, Hagino Y, Kobayashi H, Shinohara-Tanaka K, Ikeda K, Yamamoto H, Yamamoto T, Lesch KP, Murphy DL, Hall FS, Uhl GR, Sora I
(2004) Neuropsychopharmacology 29(10):1790-1799

2003

[12-1]
Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.
Narita M, Mizuo K, Mizoguchi H, Sakata M, Narita M, Tseng LF, Suzuki T
(2003) Journal of Neuroscience 23: 1006-1012

[12-3]
Reversible suppression of glutamatergic neurotransmission of cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain.
Yamamoto M, Wada N, Kitabatake Y, Watanabe D, Anzai M, Yokoyama M, Teranishi Y, Nakanishi S
(2003) Journal of Neuroscience 23: 6759-6767

[16-2]
A flow injection biosensor system for highly sensitive detection of 2,4,6-trichlorophenol based on preoxidation by ceric sulfate.
Yao T, Kotegawa K.
(2003) Analytical Sciences Jun;19(6):829-833.

[10-10]
Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.
Narita M, Mizuo K, Mizoguchi H, Sakata M, Narita M, Tseng LF, Suzuki T
(2003) Journal of Neuroscience 23: 1006-1012

[10-25]
In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.
Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I
(2003) Alcohol & Alcoholism 38: 197-201

[10-27]
Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats.
Mizuma H, Mizutani M, Nozaki S, Iizuka H, Tohyama H, Nishimura N, Watanabe Y, Kohashi R
(2003) Biochemical and Biophysical Research Communications 302: 156-161

[11-14]
Detection of 3-methoxy-4-hydroxyphenylglycol in rabbit skeletal muscle microdialysate.
Tokunaga N, Yamazaki T, Akiyama T, Mori H
(2003) Journal of Chromatography B 798: 163-166

[11-28]
Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures.
Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Inoue K
(2003) Proceedings of the National Academy of Sciences USA (PNAS) 100: 11023-11028

[12-26]
Ascorbate enhances iNOS activity by increasing tetrahydrobiopterin in RAW 264.7 cells.
Nakai K, Urushihara M, Kubota Y, Kosaka H
(2003) Free Radical Biology & Medicine 35: 929-937

[12-29]
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
(2003) Psychopharmacology (Berl) 170: 80-88

[12-30]
An immnosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress.
Fujisaki C, Utsuyama M, Kuroda Y, Watanabe A, Seidler H, Watanabe S, Kitagawa M, Hirokawa K
(2003) Journal of Medical and Dental Sciences 50: 93-100

[13-25]
Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats.
Mitsushima D, Masuda J, Kimura F.
(2003) Neuroendocrinology 78(4):234-240

2002

[10-18]
Roles of brain prostaglandin E2 and thromboxane A2 in the activation of the central sympatho-adrenomedullary outflow in rats.
Murakami Y, Okada S, Nishihara M, Yokotani K
(2002) European Journal of Pharmacology 452: 289-294

[10-22]
Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay.
Hiraku Y, Murata M, Kawanishi S
(2002) Biochimica et Biophysica Acta 1570: 47-52

[10-34]
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y
(2002) Neurochemical Research 27: 497-500

[12-13]
Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Matsuda Y, Hirano H, Watanabe Y
(2002) Brain Research 937: 58-65

[12-31]
Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide.
Mizutani H, Tada-Oikawa S, Hiraku Y, Oikawa S, Kojima M, Kawanishi S
(2002) Journal of Biological Chemistry 277: 30684-30689

[12-32]
Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate).
Tottori K, Nakai M, Uwahodo Y, Miwa T, Yamada S, Oshiro Y, Kikuchi T, Altar CA
(2002) The Journal of Pharmacology and Experimental Therapeutics 301: 249-257

[12-36]
Cliniconeuropathologic findings of familial frontal lobe epilepsy in Shetland sheepdogs.
Morita T, Shimada A, Takeuchi T, Hikasa Y, Sawada M, Ohiwa S, Takahashi M, Kubo N, Shibahara T, Miyata H, Ohama E
(2002) The Canadian Journal of Veterinary Research 66: 35-41

[13-23]
GABA release in the medial preoptic area of cyclic female rats.
Mitsushima D, Shwe TT, Funabashi T, Shinohara K, Kimura F
(2002) Neuroscience 113: 109-114

[13-24]
Profiles of in vivo gamma-aminobutyric acid release in the medial preoptic area of intact and castrated male rats.
Tin-Tin-Win-Shwe, Mitsushima D, Kimura F.
(2002) Neuroendocrinology 76(5):290-296

2001

[9-1]
beta-Phenylethlamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D2 receptor mechanism.
Kato M, Ishida K, Chuma T, Abe K, Shigenaga T, Taguchi K, Miyake T
(2001) European Journal of Pharmacology 418: 65-71

[9-3]
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+ – and K+ -evoked serotonin release.
Kawata Y, Okada M, Murakami T, Kamata A, Zhu G, Kaneko S
(2001) British Jourmal of Pharmacology 133: 557-567

[10-3]
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M
(2001) Brain Research 902: 108-118

[10-4]
Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Hatip-Al-khati I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara
(2001) Japanese Journal of Pharmacology 87: 277-287

[10-9]
Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats.
Suzuki S, Yamatoya H, Sakai M, Kataoka A, Furushiro M, Kudo S
(2001) Journal of Nutrition 131:2951-2956

[11-2]

Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neuroscience Letters 306: 206-208

[13-5]
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A
(2001) Hypertension 38: 896-901

[13-6]
Normalization of elevated hepatic 8-hydroxy-2’-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet.
Kato J, Kobune M, Nakamura T, Kuroiwa G, Takada K, Takimoto R, Sato Y, Fujikawa K, Takahashi M, Takayama T, Ikeda T, Niitsu Y
(2001) Cancer Research 61: 8697-8702

[13-7]
Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.
Matsuo I, Hirooka Y, Hironaga K, Eshima K, Shigematsu H, Shihara M, Sakai K, Takeshita A
(2001) The American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 280: R1285-1291

[8-33]
Adenosine Receptor Subtypes Modulate Two Major Functional Pathways for Hippocampal Serotonin Release.
Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S
(2001) The Journal of Neuroscience 21: 628-640

[8-34]
Monitoring of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely moving rats.
Saigusa T, Fusa K, Okutsu H, Koshikawa N
(2001) Journal of Oral Science 43: 129-134

[9-10]
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neurosci Letters 306: 206-208

[9-32]
Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs.
Yamasaki T, Tamai I, Matsumura Y
(2001)  American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 280: R1450-R1456

[9-33]
Effects of bradykinin on renal nerve stimulation-induced antidiuresis and norepinephrine overflow in anesthetized dogs.
Tadano K, Yamasaki T, Matsumura Y
(2001) Jounal of Cardiovascular Pharmacology 37: 461-470

[10-21]
Role of brain arachidonic acid cascade on central CRF1 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
Yokotani K, Murakami Y, Okada S, Hirata M
(2001) European Journal of Pharmacology 419: 183-189

[12-33]
Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.
Anzawa N, Kushikata T, Ohkawa H, Yoshida H, Kubota T, Matsuki A
(2001) Canadian Journal of Anaesthesia 48: 462-465

[12-34]
Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione.
Haramaki N, Ikeda H, Takajo Y, Katoh A, Kanaya S, Shintani S, Haramaki R, Murohara T, Imaizumi T
(2001) Arteriosclerosis, Thrombosis, and Vascular Biology 21: 1852-1856

2000

[8-6]
Reserpine Pretreatment Prevents Increase in Extracellular Striatal Dopamine Following L-DOPA Administration in Rats with Nigrostriatal Denervation.
Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M
(2000) Journal of Neurochemistry 74: 263-269

[8-12]
Preferable Monosodium Glutamate and Sodium Chloride Solutions do not Affect Diurnal Norepinephrine Release in the Rat Lateral Hypothalamus.
Smriga M, Torii K
(2000) Nutritional Neuroscience 3: 367-372

[8-13]
Presynaptic L-type Ca2+ channels on excessive dopamine release from rat caudate putamen.
Okita M, Watanabe Y, Taya K, Utsumi H, Hayashi T
(2000) Physiology & Behavior 68: 641-649

[8-21]
Fatal Severe Vasospasm Due to Rewarming Following Hypothermia -Case Report-
Jimbo H, Dohi K, Nakamura Y, Izumiyama H, Ikeda Y, Matsumoto K, Kushima M, Takaki A
(2000) Neurologia medico-chirurgica 40: 463-466

[8-29]
Interleukin-4-dependent induction of preproenkephalin in antigen-specific T helper-type 2 (Th2) cells.
Yahata T, Yahata C, Ohta A, Sekimoto M, Kitamura H, Iwakabe K, Habu S, Azuma S, Nakui M, Sato M, Koda T, Nishimura T
(2000) Journal of Neuroimmunology 105: 103-108

[10-19]
Brain phospholipase A(2)-arachidonic acid cascade is involved in the activation of central sympatho-adrenomedullary outflow in rats.
Yokotani K, Wang M, Murakami Y, Okada S, Hirata M
(2000) European Journal of Pharmacology 398: 341-347

[12-35]
Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Ludwig M, Onaka T, Yagi K
(2000) Journal of Neuroendocrinology 12: 477-479

1999

Nitric Oxide Synthase Inhibitors Induce Motor Abnormality in Mice.
Mizutani, H., Araki, T., Matsubara, M., Imai, Y., Mizugaki, M., & Itoyama, Y.
(1999)

Neuroprotective Effects of Monoamine Oxidase Inhibitor and Glutamate Receptor Inhibitor on MPTP-induced Dopamine and DOPAC Depletion in Mice
Kumagai, T., Kosaka, R., Ido, T., Araki, T., Imai, Y., Mizugaki, M., & Itoyama, Y.
(1999)

[8-7]
Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia.
Ohtani N, Sugano T, Ohta M
(1999) Brain Research 842: 6-14

[9-4]
Effect of selegiline on dopamine concentration in the striatum of a primate.
Kaseda S, Nomoto M, Iwata S
(1999) Brain Research 815: 44-50

[8-18]
Modification of acetylcholine release by nociceptin in conscious rat striatum.
Itoh K, Konya H, Takai E, Masuda H, Nagai K
(1999) Brain Research 845: 242-245

1998

[9-27]
Liquid chromatographic determination of myocardial interstitial epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Inagaki M, Alexander J, Sunagawa K
Journal of chromatography B 714: 375-378 (1998)

1997

[9-6]
Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats.
Murakami Y, Matsumoto K, Watanabe H
(1997) Biological & Pharmaceutical Bulletin 20: 88-90

[9-26]
High-performance liquid chromatographic determination of myocardial interstitial dihidroxyphenylglycol.
Takauchi Y, Kitagawa H, Kaeada T, Akiyama T, Yamazaki T
(1997) Journal of Chromatography B 693: 218-221

1995

[9-28]
Routine high-performance liquid chromatographic determination of myocardial interstitial norepinephrine.
Yamazaki T, Akiyama T, Shindo T
(1995) Journal of Chromatography B 670: 328-331

[10-20]
Elevation of plasma noradrenaline levels in urethane-anaesthetized rats by activation of central prostanoid EP3 receptors.
Yokotani K, Nishihara M, Murakami Y, Hasegawa T, Okuma Y, Osumi Y
(1995) British Journal of Pharmacology 115: 672-676

1991

[14-15]
Pineal microdialysis in freely moving rats.
Azekawa T, Sano A, Sei H, Yamamoto A, Aoi K, Morita Y
(1991) Brain Research Bulletin 26(3):413-417

1990

[14-14]
Concurrent on-line sampling of melatonin in pineal microdialysates from conscious rat and its analysis by high-performance liquid chromatography with electrochemical detection.
Azekawa T, Sano A, Aoi K, Sei H, Morita Y
(1990) Journal of Chromatography 530(1):47-55

NOx Analyzer, Model ENO-20/ENO-30

2018

Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats.
Troutman, A. D., Gallardo, E. J., Brown, M. B., & Coggan, A. R.Ishima, Y., Watanabe, K., Chuang, V. T., Takeda, I., Tawa, M., Yano, Y., Yamanaka, M., Sawano, T., Iesaki, K., Murata, Y., … & Matsumura, Y.
(2018) American Journal of Hypertension.

S‐Nitrosated alpha‐1‐acid glycoprotein exhibits antibacterial activity against multidrug‐resistant bacteria strains and synergistically enhances the effect of antibiotics.
Troutman, A. D., Gallardo, E. J., Brown, M. B., & Coggan, A. R.Ishima, Y., Watanabe, K., Chuang, V. T., Takeda, I., Kuroda, T., Ogawa, W., … & Maruyama, T.
(2018) FASEB BioAdvances.

Measurement of nitrate and nitrite in biopsy-sized muscle samples using HPLC.
Troutman, A. D., Gallardo, E. J., Brown, M. B., & Coggan, A. R.
(2018) Journal of Applied Physiology.

Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial.
Ormesher, L., Myers, J. E., Chmiel, C., Wareing, M., Greenwood, S. L., Tropea, T., … & Johnstone, E. D.
(2018) Nitric Oxide.

Platelet inhibitory effects of the Phase 3 anticancer and normal tissue cytoprotective agent, RR x‐001.
Oronsky, B., Oronsky, N., & Cabrales, P.
(2018) Journal of cellular and molecular medicine.

Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.
Majors, A. K., Chakravarti, R., Ruple, L. M., Leahy, R., Stuehr, D. J., Lauer, M., … & Aronica, M. A.
(2018) PloS one, 13(7), e0200074.

Pulmonary Hypertension and the Nitric Oxide System.
HENROHN, D.
(2018) Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1461. 83
pp. Uppsala: Acta Universitatis Upsaliensis.

Dual antiplatelet therapy with clopidogrel and aspirin increases mortality in 4T1 metastatic breast cancer-bearing mice by inducing vascular mimicry in primary tumour.
Buczek, C. W., Wietrzyk, J., & Chlopicki, S.
(2018) Oncotarget, 2018, Vol. 9, (No. 25), pp: 17810-17824

Spontaneously hypertensive rats exhibit higher sensitivity to ethanol-induced hypotensive effects: role of NMDA receptors and nitric oxide in rostral ventrolateral medulla.
Lin, H. H., Cheng, T. T., Lin, Y. C., & Lai, C. C.
(2018) Alcohol.

Hydroxyhydroquinone impairs fat utilization in mice by reducing nitric oxide availability.
Ishida, K., Misawa, K., Yamamoto, M., & Shimotoyodome, A.
(2018) The Journal of Physiological Sciences, 1-10.

Disruption of the pacemaker activity of interstitial cells of Cajal via nitric oxide contributes to postoperative ileus.
Kaji, N., Nakayama, S., Horiguchi, K., Iino, S., Ozaki, H., & Hori, M.
(2018) Neurogastroenterology & Motility.

“Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection.”
Erkens, R., Suvorava, T., Sutton, T. R., Fernandez, B. O., Mikus-Lelinska, M., Barbarino, F., … & Cortese-Krott, M. M.

Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes.
Taguchi, K., Bessho, N., Hasegawa, M., Narimatsu, H., Matsumoto, T., & Kobayashi, T.
(2018) Hypertension Research, 1.

Protective Role of Myelocytic Nitric Oxide Synthases Against Hypoxic Pulmonary Hypertension in Mice.
Ogoshi, T., Tsutsui, M., Kido, T., Sakanashi, M., Naito, K., Oda, K., … & Izumi, H.
(2018) American Journal of Respiratory and Critical Care Medicine, (ja).

Organ uptake and release of inorganic nitrate and nitrite in the pig.
Eriksson, K. E., Yang, T., Carlström, M., & Weitzberg, E.
(2018)  Nitric Oxide.

Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice.
Tanaka, A., Ito, Y., Kawasaki, H., Kitabayashi, C., Nishioka, R., Yamazato, M., … & Yamamoto, T.
(2018)  Journal of Stroke and Cerebrovascular Diseases.

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.
Shimizu, Y., Polavarapu, R., Eskla, K. L., Nicholson, C. K., Koczor, C. A., Wang, R., … & Calvert, J. W.
(2018) Journal of Molecular and Cellular Cardiology, 116, 29-40

Negatively-charged aerosol improves burn wound healing by promoting eNOS-dependent angiogenesis.
Zhao, J., Zhou, F., Chen, L., Shu, B., Zhai, Q., Wu, J., … & Xu, Y.
(2018) Am J Transl Res, 10(1), 246-255.

Dietary nitrate‐induced increases in human muscle power: high versus low responders.
Coggan, A. R., Broadstreet, S. R., Mikhalkova, D., Bole, I., Leibowitz, J. L., Kadkhodayan, A., … & Peterson, L. R.
(2018). Physiological Reports, 6(2), e13575.

Angiotensin-(1-7)-induced Mas receptor activation attenuates atherosclerosis through a nitric oxide-dependent mechanism in apolipoproteinE-KO mice.
Yang, G., Istas, G., Höges, S., Yakoub, M., Hendgen-Cotta, U., Rassaf, T., … & Rump, L. C.
(2018). Pflügers Archiv-European Journal of Physiology, 1-7.

2017

Low-dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis.
Howlin, R. P., Cathie, K., Hall-Stoodley, L., Cornelius, V., Duignan, C., Allan, R. N., … & Kelso, M.
(2017). Molecular Therapy, 25(9), 2104-2116.

“Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children.”
Al-Mashhadi, A., Checa, A., Wåhlin, N., Neveus, T., Fossum, M., Wheelock, C. E., … & Carlstrom, M.
(2017). Pediatric Nephrology, 1-11.

AFM-based detection of glycocalyx degradation and endothelial stiffening in the db/db mouse model of diabetes.
Zakrzewska, A., Gregorius, A., Sitek, B., Malek-Zietek, K. E., Jaglarz, M., Szymonski, M., … & Rajfur, Z.
(2017). Scientific Reports, 7(1), 15951.

“Clinical Trial Protocol A randomized double-blind placebo controlled cross-over trial of sodium nitrate in patients with stable angina. Inorganic Nitrate in Angina Study (INAS).”
Schwarz, K., Singh, S., Parasuraman, S. K., Bruce, M., Shepstone, L., Feelisch, M., … & Frenneaux, M.
(2017).

“Effect of Ammonium Chloride on the Methane-Oxidizing Bacterial Community 2.”
Kim, I. T., Ahn, K., Yoo, Y. S., & Kim, K. S.
(2017). Preprints

Development, validation and application of a micro–liquid chromatography–tandem mass spectrometry based method for simultaneous quantification of selected protein biomarkers of endothelial dysfunction in murine plasma.
Suraj, J., Kurpińska, A., Olkowicz, M., Niedzielska-Andres, E., Smolik, M., Zakrzewska, A., … & Walczak, M.
(2017). Journal of Pharmaceutical and Biomedical Analysis.

Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney.
Polhemus, D. J., Trivedi, R. K., Gao, J., Li, Z., Scarborough, A. L., Goodchild, T. T., … & Lefer, D. J.
(2017). Journal of the American College of Cardiology, 70(17), 2139-2153.

Breast cancer pulmonary metastasis is increased in mice undertaking spontaneous physical training in the running wheel; a call for revising beneficial effects of exercise on cancer progression.
Smeda, M., Przyborowski, K., Proniewski, B., Zakrzewska, A., Kaczor, D., Stojak, M., … & Chlopicki, S.
(2017). American Journal of Cancer Research, 7(9), 1926.

Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress.
Uchida, H., Nakajima, Y., Ohtake, K., Ito, J., Morita, M., Kamimura, A., & Kobayashi, J.
(2017). World Journal of Gastroenterology, 23(36), 6650-6664.

25-Hydroxycholecalciferol–Fortified Dairy Drink Is More Effective at Raising a Marker of Postprandial Vitamin D Status than Cholecalciferol in Men with Suboptimal Vitamin D Status.
Guo, J., Jackson, K. G., Li, Y., Givens, D. I., & Lovegrove, J. A.
(2017). The Journal of Nutrition, jn254789.

Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats.
Murata, I., Abe, Y., Yaginuma, Y., Yodo, K., Kamakari, Y., Miyazaki, Y., … & Kobayashi, J.
(2017). Annals of Intensive Care, 7(1), 90

Intravenous superoxide dismutase as a protective agent to prevent impairment of lung function induced by high tidal volume ventilation.
Wu, N. C., Liao, F. T., Cheng, H. M., Sung, S. H., Yang, Y. C., & Wang, J. J.
(2017). BMC Pulmonary Medicine, 17(1), 105.

Co-administration of Magnesium Ion Prevents Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rats.
Nagai, N., Ueno, A., Tanino, T., Oka, M., & Ito, Y.
(2017).  Biological and Pharmaceutical Bulletin, 40(6), 910-915.

Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.
Shaltout, H. A., Eggebeen, J., Marsh, A. P., Brubaker, P. H., Laurienti, P. J., Burdette, J. H., … & Morgan, T. M.
(2017).  Nitric Oxide.

Synthesis and Characterization of a Novel Organic Nitrate NDHP: Role of Xanthine Oxidoreductase-Mediated Nitric Oxide Formation.
Zhuge, Z., Paulo, L. L., Jahandideh, A., Brandão, M. C., Athayde-Filho, P. F., Lundberg, J. O., … & Montenegro, M. F.
(2017).  Redox Biology

Potential therapeutic action of nitrite in Sickle Cell Disease.
Wajih, N., Basu, S., Jailwala, A., Kim, H. W., Ostrowski, D., Perlegas, A., … & Rahbar, E.
(2017).  Redox Biology

“Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition.”
Wandrag, Liesl, Mario Siervo, Heather L. Riley, Maryam Khosravi, Bernadette O. Fernandez, Carl A. Leckstrom, Daniel S. Martin et al.
(2017).  Redox Biology

Dietary nitrite supplementation attenuates cardiac remodeling in l-NAME-induced hypertensive rats.
Sonoda, K., Ohtake, K., Uchida, H., Ito, J., Uchida, M., Natsume, H., … & Kobayashi, J.
(2017).  Nitric Oxide.

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.
Liu, X., El-Mahdy, M. A., Boslett, J., Varadharaj, S., Hemann, C., Abdelghany, T. M., … & Zweier, J. L.
(2017).  Nature Communications, 8, 14807

“METHODS AND COMPOSITIONS FOR TREATING NITRIC OXIDE DEFICIENCY DISORDERS AND RELATED CONDITIONS.”
Giordano, A., & Lefer, D. J.
(2017).  U.S. Patent No. 20,170,087,180. Washington, DC: U.S. Patent and Trademark Office.

Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.
Kina-Tanada, M., Sakanashi, M., Tanimoto, A., Kaname, T., Matsuzaki, T., Noguchi, K., … & Kubota, H.
(2017). Diabetologia, 1-14.

“Agent for preventing or ameliorating vascular endothelial malfunction.”
Morita, M., Komatsu, M., Hara, T.
(2017). United States Patent Application 20170042962

Inducible and neuronal nitric oxide synthases exert contrasting effects during rat intestinal recovery following fasting.
Ito, J., Uchida, H., Machida, N., Ohtake, K., Saito, Y., & Kobayashi, J.
(2017).  Experimental Biology and Medicine, 1535370217694434.

Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1.
Lee, E. S., Boldo, L. S., Fernandez, B. O., Feelisch, M., & Harmsen, M. C.
(2017). Scientific Reports, 7, 42487.

Effects of nitrate supplementation in trained and untrained muscle is modest with initial high plasma nitrite levels.
Christensen, P. M., Petersen, N. K., Friis, S. N., Weitzberg, E., & Nybo, L.
(2017). Scandinavian Journal of Medicine & Science in Sports.

Validation of two point-of-care tests against standard lab measures of NO in saliva and in serum.
Modi, A., Morou-Bermudez, E., Vergara, J., Patel, R., Nichols, A., & Joshipura, K.
(2017). Nitric Oxide.

Acute improvement of endothelial functions after oral ingestion of isohumulones, bitter components of beer.
Tomita, J., Mochizuki, S., Fujimoto, S., Kashihara, N., Akasaka, T., Tanimoto, M., & Yoshida, K.
(2017). Biochemical and Biophysical Research Communications

2016

From preeclampsia to renal disease: Mechanistic studies [Groningen]:
University of Groningen
van der Graaf, A. M.
(2016)

Beetroot juice versus chard gel: A pharmacokinetic and pharmacodynamic comparison of nitrate bioavailability.
McIlvenna, L. C., Monaghan, C., Liddle, L., Fernandez, B. O., Feelisch, M., Muggeridge, D. J., & Easton, C.
(2016). Nitric Oxide.

Effects of chronic nitric oxide synthase inhibition on V’O2max and exercise capacity in mice.
Wojewoda, M., Przyborowski, K., Sitek, B., Zakrzewska, A., Mateuszuk, L., Zoladz, J. A., & Chlopicki, S.
(2016). Naunyn-Schmiedeberg’s Archives of Pharmacology, 1-10.

Genetic Overexpression of the Hydrogen Sulfide Producing Enzyme Cystathionine gama-Lyase in Endothelial Cells Enhances Hydrogen Sulfide and Nitric Oxide Signaling.
Li, Z., Polhemus, D. J., Organ, C. L., Elrod, J. W., & Lefer, D. J.
(2016). Circulation, 134(Suppl 1), A17911-A17911.

Single and Combined Effects of Beetroot Crystals and Sodium Bicarbonate on 4-km Cycling Time Trial Performance.
Callahan, M. J., Parr, E. B., Hawley, J. A., & Burke, L. M.
(2016). International Journal of Sport Nutrition and Exercise Metabolism.

Profound differences between humans and rodents in the ability to concentrate salivary nitrate: Implications for translational research.
Montenegro, M. F., Sundqvist, M. L., Nihlén, C., Hezel, M., Carlström, M., Weitzberg, E., & Lundberg, J. O.
(2016). Redox Biology.

Effects of antiseptic mouthwash on resting metabolic rate: A randomized, double-blind, crossover study.
Sundqvist, M. L., Lundberg, J. O., & Weitzberg, E.
(2016). Nitric Oxide.

A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS.
Schwarz, K., Singh, S., Parasuraman, S. K., Bruce, M., Shepstone, L., Feelisch, M., … & Frenneaux, M. P.
(2016). Future Cardiology, (0).

Short-term treatment with nitrate is not sufficient to induce in vivo antithrombotic effects in rats and mice.
Kramkowski, K., Leszczynska, A., Przyborowski, K., Proniewski, B., Marcinczyk, N., Rykaczewska, U., … & Chlopicki, S.
(2016). Naunyn-Schmiedeberg’s Archives of Pharmacology, 1-10.

Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner.
Gao, Y., Stuart, D., Pollock, J. S., Takahashi, T., & Kohan, D. E.
(2016). American Journal of Physiology-Renal Physiology, ajprenal-00494.

Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.
Li, M., Tejada, T., Lambert, J. P., Nicholson, C. K., Yahiro, E., Ambai, V. T., … & Calvert, J. W.
(2016). American Journal of Cardiovascular Disease, 6(3), 118.

Consumption of a flavonoid-rich açai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men.
Alqurashi, R. M., Galante, L. A., Rowland, I. R., Spencer, J. P., & Commane, D. M.
(2016). The American Journal of Clinical Nutrition, ajcn128728.

Effects of methylphenidate on the impairment of spontaneous alternation behavior in mice intermittently deprived of REM sleep.
Niijima-Yaoita, F., Nagasawa, Y., Tsuchiya, M., Arai, Y., Tadano, T., & Tan-No, K.
(2016). Neurochemistry International.

Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats.
Matsumoto, T., Ando, M., Watanabe, S., Iguchi, M., Nagata, M., Kobayashi, S., … & Kobayashi, T.
(2016). Biological and Pharmaceutical Bulletin, 39(9), 1475-1481.

Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous congestion.
SUGAYA, K., NISHIJIMA, S., KADEKAWA, K., ASHITOMI, K., UEDA, T., & YAMAMOTO, H.
(2016). Biomedical Research, 37(4), 221-226

Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure.
Donnarumma, E., Bhushan, S., Bradley, J. M., Otsuka, H., Donnelly, E. L., Lefer, D. J., & Islam, K. N.
(2016). Journal of the American Heart Association, 5(8), e003551.

Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.
Hezel, M., Peleli, M., Liu, M., Zollbrecht, C., Jensen, B. L., Checa, A., … & Carlström, M.
(2016).  Free Radical Biology and Medicine.

In situ eNOS/NO up-regulation—a simple and effective therapeutic strategy for diabetic skin ulcer.
Yang, Y., Yin, D., Wang, F., Hou, Z., & Fang, Z.
(2016). Scientific Reports, 6, 30326.

Effects of silodosin on bladder activity in rats with frequent urination induced by pelvic venous congestion.
Sugaya, K., Nishijima, S., Kadekawa, K., Ashitomi, K., Ueda, T., & Yamamoto, H.
(2016). International Journal of Urology.

Simultaneous quantification of PGI 2 and TXA 2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method.
Kij, A., Mateuszuk, L., Sitek, B., Przyborowski, K., Zakrzewska, A., Wandzel, K., … & Chlopicki, S.
(2016). Journal of Pharmaceutical and Biomedical Analysis.

“COMPOSITIONS AND METHODS FOR PROMOTING NITRIC OXIDE PRODUCTION THROUGH AN ORAL DELIVERY SYSTEM.”
Bryan, N. S.
(2016). U.S. Patent 20,160,151,428, issued June 2, 2016.

Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling.
Polhemus, D. J., Gao, J., Scarborough, A., Trivedi, R. K., McDonough, K. H., Goodchild, T. T., … & Lefer, D. J.
(2016). Circulation Research, CIRCRESAHA-115.

High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via up-regulated ETB receptor expression.
Hyndman, K. A., Dugas, C., Arguello, A. M., Goodchild, T. T., Buckley, K. M., Burch, M., … & Pollock, J. S.
(2016). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, ajpregu-00016.

Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia.
Carlström, M., Cananau, C., Checa, A., Wide, K., Sartz, L., Svensson, A., … & Lundberg, J. O.
(2016).  Nitric Oxide.

Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II‐mediated hypertension.
Porpino, S. K., Zollbrecht, C., Peleli, M., Montenegro, M. F., Brandão, M. C., Athayde‐Filho, P. F., … & Persson, E. G.
(2016).  British Journal of Pharmacology.

Identification of Differential ER-Alpha versus ER-Beta Mediated Activation of eNOS In Uterine Artery Endothelial Cells.
Pastore, M. B., Talwar, S., Conley, M. R., & Magness, R. R.
(2016).  Biology of Reproduction, biolreprod-115.

Impaired sodium dependent adaptation of arterial stiffness in formerly preeclamptic women: The RETAP-vascular study.
van der Graaf, A. M., Paauw, N. D., Toering, T. J., Feelisch, M., Faas, M. M., Sutton, T. R., … & Navis, G.
(2016).  American Journal of Physiology-Heart and Circulatory Physiology, ajpheart-00010.

Attenuating spinal cord injury by conditioned medium from human umbilical cord blood-derived CD34+ cells in rats.
Yeng, C. H., Chen, P. J., Chang, H. K., Lo, W. Y., Wu, C. C., Chang, C. Y., … & Chen, S. H.
(2016). Taiwanese Journal of Obstetrics and Gynecology, 55(1), 85-93.

Pitavastatin Exhibits Protective Effects on Podocytes Accompanied by BMP-7 Up-Regulation and Rho Suppression.
Ohigashi, M., Imai, N., Toba, H., Kobara, M., & Nakata, T.
(2016). Pharmacology, 97(5-6), 265-276.

One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction.
Eggebeen, J., Kim-Shapiro, D. B., Haykowsky, M., Morgan, T. M., Basu, S., Brubaker, P., … & Kitzman, D. W.
(2016).  JACC: Heart Failure.

Modeling the Impact of Ingoing Sodium Nitrite, Sodium Ascorbate, and Residual Nitrite Concentrations on Growth Parameters of Listeria monocytogenes in Cooked, Cured Pork Sausage.
King, A. M., Glass, K. A., Milkowski, A. L., Seman, D. L., & Sindelar, J. J.
(2016).  Journal of Food Protection®, 79(2), 184-193.

Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor–Deficient Mice: A Comparison with Nicotinic Acid.
Mateuszuk, L., Jasztal, A., Maslak, E., Gasior-Glogowska, M., Baranska, M., Sitek, B., … & Chlopicki, S.
(2016). Journal of Pharmacology and Experimental Therapeutics, 356(2), 514-524.

Examination of neurological prognostic markers in patients with respiratory syncytial virus-associated encephalopathy.
Morichi, S., Morishita, N., Ishida, Y., Oana, S., Yamanaka, G., Kashiwagi, Y., & Kawashima, H.
(2016). International Journal of Neuroscience, (just-accepted), 1-23.

2015

Activation of regulatory T cells by endothelial cells in inflammatory skin disease
Lim, W. C.
(2015). (Doctoral dissertation, University of Southampton)

“AGENT FOR ELEVATING NITRIC OXIDE CONCENTRATION.”
Morita, M., & Kamimura, A.
(2015). U.S. Patent No. 20,150,352,067. Washington, DC: U.S. Patent and Trademark Office.

Acute Dietary Nitrate Supplementation and Exercise Performance in COPD: A Double-Blind, Placebo-Controlled, Randomised Controlled Pilot Study.
Curtis, K. J., O’Brien, K. A., Tanner, R. J., Polkey, J. I., Minnion, M., Feelisch, M., … & Hopkinson, N. S.
(2015). PLoS One, 10(12).

DL-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats.
Oosterhuis, N. R., Frenay, A. R. S., Wesseling, S., Snijder, P. M., Slaats, G. G., Yazdani, S., … & van Goor, H.
(2015). Nitric Oxide.

P2Y 2 and G q/G 11 control blood pressure by mediating endothelial mechanotransduction.
Wang, S., Iring, A., Strilic, B., Juárez, J. A., Kaur, H., Troidl, K., … & Offermanns, S.
(2015). The Journal of Clinical Investigation, 125(125 (8)), 0-0.

Physiological recycling of endogenous nitrate by oral bacteria regulates gastric mucus thickness.
El-Ferzli, G. T., Andukuri, A., Alexander, G., Scopel, M., Ambalavanan, N., Patel, R. P., & Jun, H. W.
(2015). Free Radical Biology and Medicine.

A nitric oxide releasing self-assembled peptide amphiphile nanomatrix for improving the biocompatibility of microporous hollow fibers.
Petersson, J., Jädert, C., Phillipson, M., Borniquel, S., Lundberg, J. O., & Holm, L.
(2015).ASAIO Journal.

Effects of long-term dietary nitrate supplementation in mice
Hezel, M. P., Liu, M., Schiffer, T. A., Larsen, F. J., Checa, A., Wheelock, C. E., … & Weitzberg, E.
(2015). Redox Biology.

Impact of Clean-Label Antimicrobials and Nitrite Derived from Natural Sources on the Outgrowth of Clostridium perfringens during Cooling of Deli-Style Turkey Breast.
King, A. M., Glass, K. A., Milkowski, A. L., & Sindelar, J. J.
(2015). Journal of Food Protection®, 78(5), 946-953.

1H-NMR-Based Metabolomic Analysis of Cerebrospinal Fluid From Adult Bilateral Moyamoya Disease: Comparison With Unilateral Moyamoya Disease and Atherosclerotic Stenosis.
Polhemus, D. J., Li, Z., Pattillo, C. B., Goodchild, T. T., Gojon, G., Giordano, T., & Krum, H.
(2015) Medicine, 94(17), e629.

A Novel Hydrogen Sulfide Prodrug, SG1002, Promotes Hydrogen Sulfide and Nitric Oxide Bioavailability in Heart Failure Patients.
Jeon, J. P., Yun, T., Jin, X., Cho, W. S., Son, Y. J., Bang, J. S., … & Park, S.
(2015) Nitric Oxide.

The relationship between plasma and salivary NO x.
Clodfelter, W. H., Basu, S., Bolden, C., Dos Santos, P. C., King, S. B., & Kim-Shapiro, D. B.
(2015) Cardiovascular Therapeutics.

2014

Histone deacetylas 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.
Hyndman, K. A., Ho, D. H., Sega, M. F., & Pollock, J. S.
(2014) American Journal of Physiology-Heart and Circulatory Physiology, 307(5), H803-H809

2013

Renal collecting duct Nos1 maintains fluid-electrolyte homeostasis and blood pressure novelty and significance.
Hyndman K, Boesen E, Elmarakby A, Brands M, Huang P, Kohan D, Pollock D, Pollock J.
(2013) Hypertension; 62, 91-98

Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats.
Hyndman, K. A., Xue, J., MacDonell, A., Speed, J. S., Jin, C., & Pollock, J. S.
(2013) Clinical and experimental Pharmacology and Physiology, 40(3), 233-239.

2012

Extracellular signal-regulated kinases1/2 signaling pathways are not involved in endothelin regulation of mouse inner medullary collecting duct nitric oxide production.
Hyndman K, MacDonell A, Pollock J.
(2012) Life Science 91; 578-582

2008

[15-17]
Quantifying nanomolar levels of nitrite in biological samples by HPLC-Griess method: special reference to arterio-venous difference in vivo.
Ishibashi T, Miwa T, Shinkawa I, Nishizawa N, Nomura M, Yoshida J, Kawada T, Nishio M
(2008) Tohoku Journal of Experimental Medicine; 215(1):1-11

2007

[15-11]
Methods to detect nitric oxide and its metabolites in biological samples.
Bryan NS, Grisham MB
(2007) Free Radical Biology & Medicine. 43(5):645-657. Epub 2007 Apr 29.

2005

Effects of two formulations for overcoming oketsu on vascular function and expression patterns of plasma proteins in spontaneously diabetic rats.
Li, M., Tejada, T., Lambert, J. P., Nicholson, C. K., Yahiro, E., Ambai, V. T., … & Calvert, J. W.
(2005). Journal of Traditional Medicines, 22(4), 237-243.

[13-15]
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues.
Bryan NS, Fernandez BO, Bauer SM, Garcia-Saura MF, Milsom AB, Rassaf T, Maloney RE, Bharti A, Rodriguez J, Feelisch M
(2005) Nature Chemical Biology 1: 290-297

[13-19]
Development of polyethylene glycol-conjugated poly-S-nitrosated serum albumin, a novel S-Nitrosothiol for prolonged delivery of nitric oxide in the blood circulation in vivo.
Katsumi H, Nishikawa M, Yamashita F, Hashida M
(2005) The Journal of Pharmacology and Experimental Therapeutics 314: 1117-1124

2004

[13-1]
Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep.
Okawa T, Honda S, Sanpei M, Ishida T, Fujimori K, Sato A
(2004) Journal of Perinatal Medicine 32: 495-499

[11-20]
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73

[11-29]
Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo.
Bryan NS, Rassaf T, Maloney RE, Rodriquez CM, Saijo F, Rodriguez JR, Feelisch M
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 4308-4313

2003

[10-8]
Chemical nature of nitric oxide storage forms in rat vascular tissue.
Rodriguez J, Maloney RE, Rassaf T, Bryan NS, Feelisch M
(2003) Proceeding of the National Academy of Sciences of the United States of America (PNAS) 100: 336-341. Epub 2002 Dec 26

[11-8]
Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model.
Namba T, Koike H, Murakami K, Aoki M, Makino H, Hashiya N, Ogihara T, Kaneda Y, Kohno M, Morishita R
(2003) Circulation 108: 2250-2257

[13-3]
Aspirin inhibits Chlamydia pneumoniae-induced NF-kappa B activation, cyclo-oxygenase-2 expression and prostaglandin E2 synthesis and attenuates chlamydial growth.
Yoneda H, Miura K, Matsushima H, Sugi K, Murakami T, Ouchi K, Yamashita K, Itoh H, Nakazawa T, Suzuki M, Shirai M
(2003) Journal of Medical Microbiology 52: 409-415

[11-15]
Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release.
Mochizuki S, Vink H, Hiramatsu O, Kajita T, Shigeto F, Spaan JA, Kajiya F.
(2003) American Journal of Physiology – Heart and Circulatory Physiology 285: H722-726

[11-30]
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.
Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O, Scheeren T, Godecke A, Schrader J, Schulz R, Heusch G, Schaub GA, Bryan NS, Feelisch M, Kelm M.
(2003) Free Radical Biology & Medicine 35: 790-796

2002

[10-7]
Concomitant presence of N-nitroso and S-nitroso proteins in human plasma.
Rassaf T, Bryan NS, Kelm M, Feelisch M.
(2002) Free Radical Biology & Medicine 33: 1590-1596. Erratum in: Free Radical Biology & Medicine 2003 34: 283.\

[15-9]
Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1.
Konishi F, Okada Y, Takaoka M, Gariepy CE, Yanagisawa M, Matsumura Y.
(2002) European Journal of Pharmacology 451(2):177-184.

[9-30]
Smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma.
Tsuchiya M, Asada A, Kasahara E, Sato EF, Shindo M, Inoue M.
(2002) Circulation 105: 1155-1157

[10-34]
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y.
(2002) Neurochemical Research 27: 497-500

2001

[8-28]
Cerebrospinal fluid nitric oxide metabolites are novel predictors of pain relief degenerative lumbar diseases.
Kimura S, Watanabe K, Yajiri Y, Uchiyama S, Hasegawa K, Shibuki K, Endo N.
(2001) Pain 92: 363-371

2000

[8-1]
Nitric oxide formation in the dog sphincter of Oddi from nitric oxide donors as measured with in vivo micro-dialysis.
Yamamoto I, Fujiwara M, Kuhara N, Kumano K, Yamada T, Yamamoto H, Fujiwara M
(2000) Alimentary Pharmacology & Therapeutics 14: 1095-1101

[13-4]
Potentiation of penile tumescence by T-1032, a new potent and specific phosphodiesterase type V inhibitor, in dogs.
Noto T, Inoue H, Ikeo T, Kikkawa K
(2000) The Journal of Pharmacology and Experimantal Therapeutics 294: 870-875

[8-14]
Mechanisms for Regulation of Fluid Shear Stress Response in Circulation Leukocytes.
Fukuda S, Yasu T, Predescu DN, Schmid-Schönbein GW
(2000) Circulation Research 86: e13-e18

1999

[8-8]
Psychological stress-induced enhancement of brain lipid peroxidation via nitric oxide systems and its modulation by anxiolytis and anxiogenic drugs in mice.
Matsumoto K, Yobimoto K, Huong NTT, Abdel-Fattah M, Van Hien T, Watanabe H
(1999) Brain Research 839: 74-84

Optogenetics

Top-down cortical input during NREM sleep consolidates perceptual memory
D. Miyamoto et al
(2016), Science

Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear.
Isosaka, T., Matsuo, T., Yamaguchi, T., Funabiki, K., Nakanishi, S., Kobayakawa, R., & Kobayakawa, K.
(2015). Cell, 163(5), 1153-1164.

A Top-Down Cortical Circuit for Accurate Sensory Perception.
Manita, S., Suzuki, T., Homma, C., Matsumoto, T., Odagawa, M., Yamada, K., … & Murayama, M.
(2015). Neuron.

The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice.
Sato, M., Ito, M., Nagase, M., Sugimura, Y. K., Takahashi, Y., Watabe, A. M., & Kato, F.
(2015). Molecular brain,8(1), 22.

Microdialysis

2018

In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes.
Yamada, K.
(2018). JoVE (Journal of Visualized Experiments), (139), e57869-e57869.

A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.
Saitoh, A., Soda, A., Kayashima, S., Yoshizawa, K., Oka, J. I., Nagase, H., & Yamada, M.
(2018). Journal of Pharmacological Sciences.

An enzyme-modified capillary as a platform for simultaneous fluorometric detection of D-glucose and L-lactate.
Shoji, A., Takahashi, Y., Osato, S., & Sugawara, M.
(2018). Journal of Pharmaceutical and Biomedical Analysis.

Pregabalin increases food intake through dopaminergic systems in the hypothalamus.
Ikeda, H., Yonemochi, N., Ardianto, C., Yang, L., & Kamei, J.
(2018). Brain Research.

“SIALYLATION-INCREASING THERAPIES FOR DISEASES ASSOCIATED WITH OXIDATIVE STRESS.”
Huizing, M., Malicdan, M. C., & Carrillo, N.
(2018). U.S. Patent Application No. 15/553,561.

Mesolimbic Dopamine, Its Receptors and Social Learning
Matta, R.
(2018)  (Doctoral dissertation, NOVA Science Publishers).

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.
Sobue, A., Kushima, I., Nagai, T., Shan, W., Kohno, T., Aleksic, B., … & Yamamoto, M.
(2018) Scientific Reports, 8(1), 13046.

Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity.
Lui, S., Torontali, Z., Tadjalli, A., & Peever, J.
(2018) Scientific Reports, 8(1), 12709.

A Smart and Sensitive Sensing Platform to Monitor the Extracellular of Hydrogen Peroxide in Rat Brain Microdialysate under Pathological Process based on Mesoporous Silica Nanoparticles.
Xu, G., Xie, Q., Chen, Z., Luo, F., Qiu, B., Guo, L., & Lin, Z.
(2018) Analytical Methods.

“METHODS OF TREATING PATIENTS SUFFERING FROM MOVEMENT DISORDERS.”
Kase, H., Mori, A., Waki, Y., Ohsawa, Y., Karasawa, A., & Kuwana, Y.
(2018) U.S. Patent Application No. 15/908,974.

“ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER’S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAME.”
Goshima, Y., Nakamura, F., Yamashita, N., Seo, H., Hashimoto, S., Murakami, K., … & Sasakura, Y.
(2018) U.S. Patent Application No. 15/847,740.

Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.

Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.

Stimulation of accumbal GABAB receptors inhibits delta1-and delta2-opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.
Watanabe, Y., Aono, Y., Komiya, M., Waddington, J. L., & Saigusa, T.
(2018) European Journal of Pharmacology.

Translocator protein 18kDa antagonist ameliorates stress‐induced stool abnormality and abdominal pain in rodent stress models.
Kawahara, Y., Mitsui, K., Niwa, T., Morimoto, N., Kawaharada, S., & Katsumata, S.
(2018) Neurogastroenterology & Motility, e13425.

Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies.
Wang, J., Jin, W. S., Bu, X. L., Zeng, F., Huang, Z. L., Li, W. W., … & Zhu, J.
(2018) Acta Neuropathologica, 1-12.

Surgical Reinforcement Alters Collagen Alignment and Turnover in Healing Myocardial Infarcts.
Caggiano, L. R., Lee, J. J., & Holmes, J. W.
(2018) American Journal of Physiology-Heart and Circulatory Physiology.

Central apelin administration and restraint stress induce hypothalamic cholecystokinin release through APJ receptor.
Bülbül, M., Sinen, O., Abueid, L., Akkoyunlu, G., & Özsoy, Ö.
(2018) Journal of neuroendocrinology, e12635.

Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice.
Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., … & Kinoshita, H.
(2018) Neuroscience Letters.

Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex.
Saiki, M., Matsui, T., Soya, M., Kashibe, T., Shima, T., Shimizu, T., … & Soya, H.
(2018) Scientific reports, 8(1), 10469.

Escitalopram Attenuates Fear Stress-Induced Increase in Amygdalar Dopamine Following Methamphetamine-induced Sensitisation: Implications of Fine-Tuning Action of Selective Serotonin Reuptake Inhibitors on Emotional Processing.
Muraoka, H., Oshibuchi, H., Kawano, M., Kawano, T., Tsutsumi, T., Yamada, M., … & Inada, K.
(2018) European Journal of Pharmacology.

Female Japanese quail visually differentiate testosterone-dependent male attractiveness for mating preferences.
Hiyama, G., Mizushima, S., Matsuzaki, M., Tobari, Y., Choi, J. H., Ono, T., … & Sugita, S.
(2018) Scientific Reports, 8(1), 10012.

A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats.
Zeng, Y., Hu, D., Yang, W., Hayashinaka, E., Wada, Y., Watanabe, Y., … & Cui, Y.
(2018) NeuroImage.

Rapid Intracellular Zn 2+ Dysregulation via Membrane Corticosteroid Receptor Activation Affects In Vivo CA1 LTP.
Suzuki, M., Sato, Y., Tamura, K., Tamano, H., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.

Diazepam suppresses the stress-induced dopaminergic release in the amygdala of methamphetamine-sensitized rat.
Kawano, T., Oshibuchi, H., Kawano, M., Muraoka, H., Tsutsumi, T., Yamada, M., … & Inada, K.
(2018) European Journal of Pharmacology.

Involvement of NMDA receptors, nitric oxide and GABA in rostral ventrolateral medulla in acute ethanol‐induced cardiovascular responses in rats.
Lo, H., Lin, H. H., Chen, J. K., Situmorang, J. H., & Lai, C. C.
(2018) Alcoholism: Clinical and Experimental Research.

A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis and downregulates equilibrative nucleoside transporter 1.
Sharma, R., Sahota, P., & Thakkar, M. M.
(2018) Journal of Neurochemistry.

Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer’s disease models.
Higaki, S., Muramatsu, M., Matsuda, A., Matsumoto, K., Satoh, J. I., Michikawa, M., & Niida, S.
(2018) PLOS ONE, 13(5), e0196929.

Extracellular Zn 2+ Influx into Nigral Dopaminergic Neurons Plays a Key Role for Pathogenesis of 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats.
Tamano, H., Nishio, R., Morioka, H., & Takeda, A.
(2018)  Molecular neurobiology, 1-9.

Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo
Yuan, X., Fei, F., Sun, H., Xiao, C., Zhao, X., Zhang, Y., & Zheng, X.
(2018)  International journal of nanomedicine, 13, 2265.

Fear memory consolidation in sleep requires protein kinase A.
Cho, J., Sypniewski, K. A., Arai, S., Yamada, K., Ogawa, S., & Pavlides, C.
(2018)  Learning & Memory, 25(5), 241-246.

Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity.
Kehr, J., Yoshitake, T., Ichinose, F., Yoshitake, S., Kiss, B., Gyertyán, I., & Adham, N.
(2018) Psychopharmacology, 1-15.

Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity.
Hayashida, K. I., Kimuram, M., & Eisenach, J. C.
(2018) Neuroscience Letters.

Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Igarashi, H., Ikeda, K., Onimaru, H., Kaneko, R., Koizumi, K., Beppu, K., … & Kobayashi, K.
(2018) Scientific Reports, 8(1), 5435.

Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with b-amyloid in rats.
Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences, 30, 1e6.

Age-related and function-dependent regional alterations of free L-and D-aspartate in postembryonic chick brain.
Zachar, G., Jakó, T., Vincze, I., Wagner, Z., Tábi, T., Bálint, E., … & Csillag, A.
(2018) Acta Biologica Hungarica, 69(1), 1-15.

Functional mechanism of ASP5736, a selective serotonin 5-HT 5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia.
Yamazaki, M., Yamamoto, N., Yarimizu, J., Okabe, M., Moriyama, A., Furutani, M., … & Harada, K.
(2018) European Neuropsychopharmacology.

Insular cortex inactivation generalizes fear-induced underestimation of interval timing in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.

Effects of mild perinatal hypothyroidism on cognitive function of adult male offspring.
Amano, I., Takatsuru, Y., Khairinisa, M. A., Kokubo, M., Haijima, A., & Koibuchi, N.
(2018) Endocrinology.

Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia.
Kiso, T., Moriyama, A., Furutani, M., Matsuda, R., & Funatsu, Y.
(2018) European Journal of Pharmacology.

Mass Spectrometric Analysis of Neurologically-Relevant Molecules.
Smith, C. L.
(2018) Doctoral dissertation, The University of Arizona.

Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition.
Wang, X., Ma, S., Wu, H., Shen, X., Xu, S., Guo, X., … & Wang, F.
(2018) Experimental & Molecular Medicine, 50(2), e445.

Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats.
Egashira, N., Akiyoshi, Y., Iba, H., Arai, T., Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences.

Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice.
Tanaka, A., Ito, Y., Kawasaki, H., Kitabayashi, C., Nishioka, R., Yamazato, M., … & Yamamoto, T.
(2018)  Journal of Stroke and Cerebrovascular Diseases.

Determination of the Target Temperature Required to Block Increases in Extracellular Glutamate Levels During Intraischemic Hypothermia.
Sato, S., Takeda, Y., Mizoue, R., Kawase, H., Fushimi, M., Shimizu, T., & Morimatsu, H.
(2018)  Therapeutic Hypothermia and Temperature Management.

[EXPRESS] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
Watanabe, M., Narita, M., Hamada, Y., Yamashita, A., Tamura, H., Ikegami, D., … & Muto, A.
(2018)  Molecular Pain, 1744806918756406.

Ketamine-induced prefrontal serotonin release is mediated by cholinergic neurons in the pedunculopontine tegmental nucleus.
Kinoshita, H., Nishitani, N., Nagai, Y., Andoh, C., Asaoka, N., Kawai, H., … & Kaneko, S.
(2018)  International Journal of Neuropsychopharmacology.

Delayed administration of BQ788, an ETB antagonist, after experimental traumatic brain injury promotes recovery of blood–brain barrier function and reduction of cerebral edema in mice.
Michinaga, S., Kimura, A., Hatanaka, S., Minami, S., Asano, A., Ikushima, Y., … & Koyama, Y.
(2018) Journal of Neurotrauma, (ja)

[EXPRESS] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: analysis using a microdialysis/mass spectrometry integrated system.
Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., … & Narita, M.
(2018) Molecular Pain, 1744806918754934.

2017

“CNS hormonal and nutritional regulation of glucose and energy homeostasis.”
Abraham, M.
(2017) Doctoral dissertation

PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity.
Dang, D. K., Shin, E. J., Kim, D. J., Tran, H. Q., Jeong, J. H., Jang, C. G., … & Kim, H. C.
(2017) Free Radical Biology and Medicine.

The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia.
Nogami-Hara, A., Nagao, M., Takasaki, K., Egashira, N., Fujikawa, R., Kubota, K., … & Iwasaki, K.
(2017) Journal of Ethnopharmacology.

δ-Subunit Containing GABA A Receptors Modulate Respiratory Networks.
Montandon, G., Wu, H., Liu, H., Vu, M. T., Orser, B. A., & Horner, R. L.
(2017) Scientific Reports, 7(1), 18105.

Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice.
Park, S. H., Eber, M. R., Tsuzuki, S., Booker, M. E., Sunil, A. G., Widner, D. B., … & Shiozawa, Y.
(2017) Scientific reports, 7(1), 17428.

Region‐specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
Sugimoto, J., Tanaka, M., Sugiyama, K., Ito, Y., Aizawa, H., Soma, M., … & Tanaka, K.
(2017) Glia.

Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats.
Akagi, K., Yamada, M., Saitoh, A., Oka, J. I., & Yamada, M
(2017) Neuropharmacology.

Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning.
Hara, S., Kobayashi, M., Kuriiwa, F., Ikematsu, K., & Mizukami, H.
(2017) Toxicology.

Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit.
Fu, K., Miyamoto, Y., Sumi, K., Saika, E., Muramatsu, S. I., Uno, K., & Nitta, A.
(2017) PLoS One, 12(12), e0189006.

“METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS.”
Davidson, Beverly L., Bradley T. Hyman, and Eloise Hudry.
(2017) Patent 20,170,336,395, issued November 23, 2017.

Smaller effect of propofol than sevoflurane anesthesia on dopamine turnover induced by methamphetamine and nomifensine in the rat striatum: an in vivo microdialysis study.
TAHARABARU, S., SATOMOTO, M., TAMURA, T., & ADACHI, Y. U.
(2017) Experimental Animals, 17-0092.

Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
Kárpáti, A., Mogi, A., Yanai, A., Naganuma, F., Yanai, K., Okamura, N., … & Iida, T.
(2017) Scientific Reports, 7(1), 1.

β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system.
Ohara, K., Fukuda, T., Ishida, Y., Takahashi, C., Ohya, R., Katayama, M., … & Nagai, K.
(2017) Scientific Reports, 7(1), 15785.

Syntaxin1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Fujiwara, T., Kofuji, T., Mishima, T., & Akagawa, K.
(2017) European Journal of Neuroscience.

Moderate intensity, exercise-induced catecholamine release in the preoptic area and anterior hypothalamus in rats is enhanced in a warm environment.
Zheng, X., Takatsu, S., Ishikawa, R., & Hasegawa, H.
(2017) Journal of Thermal Biology.

Changes in thermoregulation and monoamine release in freely moving rats during cold exposure and inhibition of the ventromedial, dorsomedial, or posterior hypothalamus.
Ishiwata, T., & Greenwood, B. N.
(2017) Journal of Comparative Physiology B, 1-11.

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23.
Deyama, S., Shimoda, K., Suzuki, H., Ishikawa, Y., Ishimura, K., Fukuda, H., … & Shuto, S.
(2017) Psychopharmacology, 1-8.

The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.
Yoshida, R., Shin, M., Yasumatsu, K., Takai, S., Inoue, M., Shigemura, N., … & Ninomiya, Y.
(2017) Frontiers in Physiology, 8, 866.

Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.
Li, Y., Yin, A., Sun, X., Zhang, M., Zhang, J., Wang, P., … & Wang, H.
(2017) The Journal of Clinical Investigation, 127(12)

Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice.
Gölöncsér, F., Baranyi, M., Balázsfi, D., Demeter, K., Haller, J., Freund, T. F., … & Sperlágh, B.
(2017) Frontiers in Molecular Neuroscience, 10, 325.

Involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex.
Ishiwata, S., Umino, A., & Nishikawa, T.
(2017) Neurochemistry International.

Subthalamic Nucleus and Globus Pallidus Interna Influence Firing of Tonically Active Neurons in the Primate Striatum through Different Mechanisms.
Nakajima, A., Shimo, Y., Uka, T., & Hattori, N.
(2017) European Journal of Neuroscience, 10.1111/ejn.13726.

The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain.
Du, J., Fang, J., Wen, C., Shao, X., Liang, Y., & Fang, J.
(2017) Neural Plasticity, 2017.

Stimulation of accumbal GABA A receptors inhibits delta2-, but not delta1-, opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.
Aono, Y., Kiguchi, Y., Watanabe, Y., Waddington, J. L., & Saigusa, T.
(2017) European Journal of Pharmacology.

Striatal N-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice.
Miyamoto, Y., Iegaki, N., Fu, K., Ishikawa, Y., Sumi, K., Azuma, S., … & Nitta, A.
(2017) International Journal of Neuropsychopharmacology.

The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice.
Saitoh, A., Suzuki, S., Soda, A., Ohashi, M., Yamada, M., Oka, J. I., … & Yamada, M.
(2017) Behavioural Brain Research.

Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug.
Yamamoto, S., Ushio, S., Egashira, N., Kawashiri, T., Mitsuyasu, S., Higuchi, H., … & Masuda, S.
(2017) Scientific Reports, 7.

Perfusion with carbon monoxide does not affect extracellular glutamate in dialysates of the hippocampus of freely moving mice.
Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Miki, T., & Kinoshita, H.
(2017) Drug and Chemical Toxicology, 1-3.

Ginsenoside Re Protects Trimethyltin-Induced Neurotoxicity via Activation of IL-6-Mediated Phosphoinositol 3-Kinase/Akt Signaling in Mice.
Tu, T. H. T., Sharma, N., Shin, E. J., Tran, H. Q., Lee, Y. J., Jeong, J. H., … & Ko, S. K.
(2017)  Neurochemical Research, 1-15.

Alpha-PVP induces the rewarding effect via activating dopaminergic neuron.
Hataoka, K., Kaizaki-Mitsumoto, A., & Numazawa, S.
(2017)  The Journal of Toxicological Sciences, 42(5), 539-543

Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway.
Shimizu, S., Sogabe, S., Yanagisako, R., Inada, A., Yamanaka, M., Iha, H. A., & Ohno, Y.
(2017)  International journal of molecular sciences, 18(7), 1416.

Characterization of CRF 1 receptor antagonists with differential peripheral vs central actions in CRF challenge in rats.
Tanaka, M., Tomimatsu, Y., Sakimura, K., Ootani, Y., Sako, Y., Kojima, T., … & Hirai, K
(2017) Peptides.

Evidence for Tonic Control by the GABAA Receptor of Extracellular D-Serine Concentrations in the Medial Prefrontal Cortex of Rodents.
Umino, A., Ishiwata, S., Iwama, H., & Nishikawa, T.
(2017) Frontiers in Molecular Neuroscience, 10, 240

The effect of electroacupuncture on PKMzeta in the ACC in regulating.
Du, J., Fang, J., Wen, C., Shao, X., Liang, Y., & Fang, J.
(2017)

A novel LRP1-binding peptide L57 that crosses the blood brain barrier.
Sakamoto, K., Shinohara, T., Adachi, Y., Asami, T., & Ohtaki, T.
(2017) Biochemistry and Biophysics Reports.

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice.
Hara, Y., Ago, Y., Taruta, A., Hasebe, S., Kawase, H., Tanabe, W., … & Takuma, K.
(2017) Psychopharmacology, 1-12.

Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the.
Matsunami, S., Ogura, Y., Amita, H., Izumi, T., Yoshioka, M., & Matsushima, T.
(2017) Behavioural Brain Research, 233(2), 577-586.

Role of microglia in mechanical allodynia in the anterior cingulate cortex.
Miyamoto, K., Kume, K., & Ohsawa, M.
(2017) Journal of Pharmacological Sciences.

Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model.
Ishikawa, Y., Deyama, S., Shimoda, K., Yoshikawa, K., Ide, S., Satoh, M., & Minami, M.
(2017) Behavioural Brain Research.

Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats.
Ishiwata, T., Hasegawa, H., & Greenwood, B. N
(2017) Neuroscience Letters.

Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat.
Shimaoka, H., Kawaguchi, T., Morikawa, K., Sano, Y., Naitou, K., Nakamori, H., … & Shimizu, Y.
(2017) Journal of Physiological Sciences, 1-6

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation.
Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K., … & Koizumi, S.
(2017) Cell Reports, 19(6), 1151-1164.

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential.
Sandweiss, A. J., McIntosh, M. I., Moutal, A., Davidson-Knapp, R., Hu, J., Giri, A. K., … & Vanderah, T. W.
(2017) Molecular Psychiatry.

The involvement of brain-derived neurotrophic factor in 3, 4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization.
Mouri, A., Noda, Y., Niwa, M., Matsumoto, Y., Mamiya, T., Nitta, A., … & Nabeshima, T.
(2017) Behavioural Brain Research.

A novel 5HT3 receptor–IGF1 mechanism distinct from SSRI-induced antidepressant effects.
Kondo, M., Koyama, Y., Nakamura, Y., & Shimada, S.
(2017) Molecular Psychiatry.

Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption.
Sharma, R., Sahota, P., & Thakkar, M. M.
(2017) Journal of Neurochemistry.

A novel device for continuous long-term electroencephalogram recording and drug administration in mice with a nice, powerful and sophisticated wired system.
Watanabe, S., Saito, M., Soma, M., Miyaoka, H., & Takahashi, M.
(2017) Journal of Neuroscience Methods.

Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: differential responses to drug treatment.
Minami, S., Satoyoshi, H., Ide, S., Inoue, T., Yoshioka, M., & Minami, M.
(2017) Neuroscience Letters.

Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Chen, M., Hoshino, H., Saito, S., Yang, Y., & Obata, H.
(2017) Neuroscience Letters.

Involvement of intracellular Zn2+ signaling in LTP at perforant pathway‐CA1 pyramidal cell synapse.
Tamano, H., Nishio, R., & Takeda, A.
(2017) Hippocampus.

Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice.
Alkam, T., Mamiya, T., Kimura, N., Yoshida, A., Kihara, D., Tsunoda, Y., … & Nabeshima, T.
(2017) Psychopharmacology, 1-17.

Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Shimohata, A., Ishihara, K., Hattori, S., Miyamoto, H., Morishita, H., Ornthanalai, G., … & Sago, H.
(2017) Experimental Neurology.

Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer’s disease rat model.
Moriyama, H., Watanabe, T., Takasaki, K., Nagao, M., Kubota, K., Katsurabayashi, S., … & Iwasaki, K.
(2017) Traditional & Kampo Medicine.

Activation of the NMDA receptor–neuronal nitric oxide synthase pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain.
Deyama, S., Sugano, Y., Mori, S., Amano, T., Yoshioka, M., Kaneda, K., & Minami, M.
(2017) Neuropharmacology.

A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells.
Nagai, N., Ito, Y., Shibata, T., Kubo, E., & Sasaki, H.
(2017) Toxicology.

In vitro and in vivo physiology of low nanomolar concentrations of Zn2+ in artificial cerebrospinal fluid.
Tamano, H., Nishio, R., Shakushi, Y., Sasaki, M., Osawa, M., & Takeda, A.
(2017) Scientific Reports, 7, 42897.

Differential requirements of hippocampal de novo protein and mRNA synthesis in two long-term spatial memory tests: Spontaneous place recognition and delay-interposed radial maze performance in rats.
Ozawa, T., Yamada, K., & Ichitani, Y.
(2017) PloS one, 12(2), e0171629.

Maintained LTP and Memory Are Lost by Zn2+ Influx into Dentate Granule Cells, but Not Ca2+ Influx.
Takeda, A., Tamano, H., Hisatsune, M., Murakami, T., Nakada, H., & Fujii, H.
(2017) Molecular Neurobiology, 1-11.

Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity.
Natsubori, A., Tsustui-Kimura, I., Nishida, H., Bouchekioua, Y., Sekiya, H., Uchigashima, M., … & Tanaka, K. F.
(2017) Journal of Neuroscience, 3377-16.

Oral administration of methylphenidate (Ritalin) differentially affects dopamine release between the prefrontal cortex and striatum-a microdialysis study in the monkey.
Kodama, T., Kojima, T., Honda, Y., Hosokawa, T., Tsutsui, K. I., & Watanabe, M.
(2017) Journal of Neuroscience, 2155-16.

Blockade of intracellular Zn 2+ signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP.
Fujise, Y., Kubota, M., Suzuki, M., Tamano, H., & Takeda, A.
(2017) Neurochemistry International.

Involvement of lateral habenula α1 subunit-containing GABA A receptor-mediated inhibitory transmission in the regulation of depression-related behaviors in experimental Parkinson’s disease.
Wang, T., Zhang, L., Zhang, Q. J., Wang, Y., Du, C. X., Sun, Y. N., … & Liu, J.
(2017) Neuropharmacology.

Pharmacological properties of SAK3, a novel T-type voltage-gated Ca 2+ channel enhancer.
Yabuki, Y., Matsuo, K., Izumi, H., Haga, H., Yoshida, T., Wakamori, M., … & Fukunaga, K.
(2017) Neuropharmacology.

Basic Study Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
Huang, H. H., Chen, C. Y., Ting, C. H., Syu, Y. F., & Chang, S. C.
(2017) Name of Journal: World Journal of Gastroenterology ESPS Manuscript NO: 28232 Manuscript Type: ORIGINAL ARTICLE

Glutamatergic modulation of noradrenaline release in the rat median preoptic area.
Takahashi, M., Hayashi, Y., & Tanaka, J.
(2017) Brain Research Bulletin.

2016

Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice.
Tanaka, T., Ago, Y., Umehara, C., Imoto, E., Hasebe, S., Hashimoto, H., … & Matsuda, T.
(2016) International Journal of Neuropsychopharmacology, pyw115.

Exploring the mechanism by which accumbal deep brain stimulation attenuates morphine-induced reinstatement through manganese-enhanced MRI and pharmacological intervention.
Zhang, L., Cui, Y., Wang, Y. C., Yin, H., Zheng, J. M., Huang, L., … & Li, J.
(2016) Experimental Neurology.

Controlling the length of short electrospun polymer nanofibers via the addition of micro-spherical silica particles.
Yabuki, A., Motonobu, E., & Fathona, I. W.
Journal of Materials Science, 1-9.

Correlation between colonic secretion and colonic motility in rats: Role of ghrelin.
Huang, H. H., Ting, C. H., Syu, Y. F., Chang, S. C., & Chen, C. Y.
(2016) World J Gastroenterol, 22(46), 10140-10147.

Betaine attenuates memory impairment after water-immersion restraint stress and is regulated by the GABAergic neuronal system in the hippocampus.
Kunisawa, K., Kido, K., Nakashima, N., Matsukura, T., Nabeshima, T., & Hiramatsu, M.
(2016) European Journal of Pharmacology.

Noradrenaline receptor mechanisms modulate the angiotensin II-induced water intake in the subfornical organ in rats.
Takahashi, M., & Tanaka, J.
(2016) Experimental Brain Research, 1-7.

Induction of antinociceptive tolerance to the chronic intrathecal administration of apelin-13 in rat.
Abbasloo, E., Najafipour, H., & Esmaeili-Mahani, S.
(2016) Neuropeptides, 60, 7-12.

Opposite effects of central oxytocin and arginine vasopressin on changes in gastric motor function induced by chronic stress.
Bülbül, M., Sinen, O., Gemici, B., & İzgüt-Uysal, V. N.
(2016) Peptides, 87, 1-11.

Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
Yue, J. T., Abraham, M. A., Bauer, P. V., LaPierre, M. P., Wang, P., Duca, F. A., … & Lam, T. K.
(2016) Nature Communications, 7, 13501

Neuropeptide EI-induced paradoxical sleep in rats.
Fujimoto, M., Fukuda, S., Sakamoto, H., Takata, J., & Sawamura, S.
(2016) Peptides.

Activation of mu-opioid receptors in the ventral pallidum decreases the negative hedonic evaluation of a conditioned aversive taste in rats.
Inui, T., & Shimura, T.
(2016) Behavioural Brain Research.

Opposite Effects of Central Oxytocin and Arginine Vasopressin on Changes in Gastric Motor Function Induced by Chronic Stress.
Bülbül, M., Sinen, O., Gemici, B., & İzgüt-Uysal, V. N.
(2016) Peptides.

Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain.
Zahid, H. M., Ferdaus, M. Z., Ohara, H., Isomura, M., & Nabika, T.
(2016) Scientific Reports, 6, 36739.

The role of inversely operating glutamate transporter in the paradoxical analgesia produced by glutamate transporter inhibitors.
Kim, W. M., Chae, J. W., Heo, B. H., Park, K. S., Kim, H. S., Lee, H. G., … & Yoon, M. H.
(2016) European Journal of Pharmacology

The Role of Adenosine in the Maturation of Sleep Homeostasis in Rats.
Gvilia, I., Suntsova, N., Kostin, A., Kalinchuk, A., McGinty, D., Basheer, R., & Szymusiak, R.
(2016) Journal of Neurophysiology, jn-00675

15-deoxy-Δ 12, 14-prostaglandin J 2 induced neurotoxicity via suppressing phosphoinositide 3-kinase.
Koma, H., Yamamoto, Y., Nishi, A., & Yagami, T.
(2016) Neuropharmacology.

Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.
Tokunaga, R., Shimoju, R., Shibata, H., & Kurosawa, M
(2016) The Journal of Physiological Sciences, 1-10.

PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice.
Shin, E. J., Dang, D. K., Tran, H. Q., Nam, Y., Jeong, J. H., Lee, Y. H., … & Nabeshima, T.
(2016) Neurochemistry International.

Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors.
Montandon, G., Liu, H., & Horner, R. L.
(2016) Scientific Reports, 6, 32707.

Mapping the influence of electrospinning parameters on the morphology transition of short and continuous nanofibers.
Fathona, I. W., & Yabuki, A.
(2016) Fibers and Polymers, 17(8), 1238-1244.

Equilibrative Nucleoside Transporter ENT1 as a Biomarker of Huntington Disease.
Guitart, X., Bonaventura, J., Rea, W., Orrú, M., Cellai, L., Dettori, I., … & Chang, C. P.
(2016) Neurobiology of Disease.

Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model.
Moon, H. C., Lee, Y. J., Cho, C. B., & Park, Y. S.
(2016) Neuroscience Letters.

Sex differences in abuse-related neurochemical and behavioral effects of 3, 4-methylenedioxymethamphetamine (MDMA) in rats.
Lazenka, M. F., Suyama, J. A., Bauer, C. T., Banks, M. L., & Negus, S. S.
(2016) Pharmacology Biochemistry and Behavior.

Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters.
Solis Jr, E., Suyama, J. A., Lazenka, M. F., DeFelice, L. J., Negus, S. S., Blough, B. E., & Banks, M. L.
(2016) Scientific Reports, 6, 31385.

Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion.
Umezu, T., & Shibata, Y.
(2016) Toxicology Reports, 3, 552-562.

Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice.
Sagawa, Y., Sato, M., Sakai, N., Chikahisa, S., Chiba, S., Maruyama, T., … & Nishino, S.
(2016) Neuropharmacology.

Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats.
Yang, F., Zhou, L., Wang, D., Yang, L. L., Yuan, G. R., & Huang, Q. Y.
(2016) Scientific Reports, 6, 30168.

GABAergic Modulation of Serotonin Release in the Rat Subfornical Organ Area.
Takahashi, M., Nomura, M., & Tanaka, J.
(2016) Neuroscience Letters.

Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia.
Tamano, H., Ide, K., Adlard, P. A., Bush, A. I., & Takeda, A.
(2016) The Journal of Toxicological Sciences, 41(4), 449-457.

In vivo neurochemical evidence that delta1-, delta2-and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats.
Kiguchi, Y., Aono, Y., Watanabe, Y., Yamamoto, S., Shimizu, K., Shimizu, T., … & Saigusa, T.
(2016) European Journal of Pharmacology.

Neurochemical Substrates of Asymmetrical Sleep in the Fur Seal.
Lapierre, J. L.
(2016) Doctoral dissertation, University of Toronto.

The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain.
Kim, D. Y., Chae, J. W., Lim, C. H., Heo, B. H., Park, K. S., Lee, H. G., … & Kim, W. M.
(2016) The Korean Journal of Pain, 29(3), 164-171.

Involvement of GABAA.
Ago, Y., Hasebe, S., Hiramatsu, N., Mori, K., Watabe, Y., Onaka, Y., … & Matsuda, T.
(2016) Psychopharmacology, 1-10.

Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain.
Kato, T., Ide, S., & Minami, M.
(2016) Neuroscience Letters.

Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion.
Umezu, T., & Shibata, Y.
(2016) Toxicology Reports.

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.
Tokudome, K., Okumura, T., Shimizu, S., Mashimo, T., Takizawa, A., Serikawa, T., … & Ohno, Y.
(2016) Scientific Reports, 6, 27420.

Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine.
Ip, J. Y., Sone, M., Nashiki, C., Pan, Q., Kitaichi, K., Yanaka, K., … & Nakagawa, S.
(2016) Scientific Reports, 6, 27204

Effects of propofol on the dopamine, metabolites and GABAA receptors in media prefrontal cortex in freely moving rats.
Wang, Y., Yu, T., Yuan, C., Yuan, J., Luo, Z., Pan, Y., … & Yu, B.
(2016) Am J Transl Res, 8(5), 2301-2308.

Motor Training Promotes Both Synaptic and Intrinsic Plasticity of Layer II/III Pyramidal Neurons in the Primary Motor Cortex.
Kida, H., Tsuda, Y., Ito, N., Yamamoto, Y., Owada, Y., Kamiya, Y., & Mitsushima, D.
(2016) Cerebral Cortex, bhw134.

Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum.
Fuwa, T., Suzuki, J., Tanaka, T., Inomata, A., Honda, Y., & Kodama, T.
(2016) The Journal of Toxicological Sciences, 41(3), 329-337.

“Acute and Chronic Effects of Inhalants in Intracranial Self-stimulation.”
Tracy, Matthew.
(2016)

GABA B receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia.
Li, G., Lv, J., Wang, J., Wan, P., Li, Y., Jiang, H., & Jin, Q.
(2016) Brain Research Bulletin.

Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors.
Miyazaki, Y., Sunaga, H., Hobo, S., Miyano, K., & Uezono, S.
(2016) Journal of Anesthesia, 1-6.

Mirtazapine exerts an anxiolytic-like effect through activation of the median raphe nucleus-dorsal hippocampal 5-HT pathway in contextual fear conditioning in rats.
An, Y., Chen, C., Inoue, T., Nakagawa, S., Kitaichi, Y., Wang, C., … & Kusumi, I.
(2016) Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Serotonin release in the subfornical organ area induced by sodium and water intake in the rat.
Takahashi, M., & Tanaka, J.
(2016) Physiology & Behavior.

Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., … & Bae, H.
(2016) The Journal of Clinical Investigation, 126(5).

Dopamine dynamics during emotional cognitive processing: implications of the specific actions of clozapine compared with haloperidol.
Kawano, M., Oshibuchi, H., Kawano, T., Muraoka, H., Tsutsumi, T., Yamada, M., … & Ishigooka, J.
(2016) European Journal of Pharmacology

Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., … & Bae, H.
(2016) The Journal of Clinical Investigation, 126(5).

A Clock mutation enhances light-phase responsiveness to cocaine in locomotor activity and self-administration with impulsive-like responding in mice.
Meng, H., Murakami, G., Suenaga, T., Edamura, M., Doi, M., Ishida, Y., … & Nakahara, D.
(2016) Psychopharmacology, 1-8.

Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT.
Mori, T., Uzawa, N., Iwase, Y., Masukawa, D., Rahmadi, M., Hirayama, S., … & Suzuki, T.
(2016) Psychopharmacology, 1-11

Unusual social behavior in HPC‐1/syntaxin1A knockout mice is caused by disruption of the oxytocinergic neural system.
Fujiwara, T., Sanada, M., Kofuji, T., & Akagawa, K.
(2016) Journal of Neurochemistry.

Involvement of hippocampal NMDA receptors in retrieval of spontaneous object recognition memory in rats
Iwamura, E., Yamada, K., & Ichitani, Y.
(2016) Behavioural Brain Research.

Brain Site-and Transmitter-dependent Actions of Methamphetamine, Morphine and Antipsychotics.
Mori, T., Iwase, Y., Murata, A., Iwata, N., & Suzuki, T
(2016) Behavioural Brain Research.

5‐HT (1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K/Akt/mTOR activation‐induced NLRP3 activity.
Qiu, Y., Huang, X., Huang, L., Tang, L., Jiang, J., Chen, L., & Li, S.
(2016) IUBMB life.

Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats.
Hazama, Y., Maekawa, T., Miki, R., Oshima, S., Egawa, Y., Morimoto, K., & Seki, T
(2016) Biological and Pharmaceutical Bulletin, 39(3), 343-352.

Non-invasive determination of glucose directly in raw fruits using a continuous flow system based on microdialysis sampling and amperometric detection at an integrated enzymatic biosensor.
Vargas, E., Ruiz, M. A., Campuzano, S., Reviejo, A. J., & Pingarrón, J. M
(2016) Analytica Chimica Acta.

Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice.
Watanabe, C., Mizoguchi, H., Bagetta, G., & Sakurada, S.
(2016) Neuroscience Letters.

Neuropeptide Y signaling in the dorsal raphe nucleus inhibits male sexual behavior in mice.
Inaba, A., Komori, Y., Muroi, Y., Kinoshita, K. I., & Ishii, T.
(2016) Neuroscience.

Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and gaba neurons.
Ardianto, C., Yonemochi, N., Yamamoto, S., Yang, L., Takenoya, F., Shioda, S., … & Kamei, J.
(2016) Neuroscience.

Opposing Roles of Cholinergic and GABAergic Activity in the Insular Cortex and Nucleus Basalis Magnocellularis during Novel Recognition and Familiar Taste Memory Retrieval.
Rodríguez-García, G., & Miranda, M. I.
(2016) The Journal of Neuroscience, 36(6), 1879-1889.

The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat.
Shahbazi-Gahrouei, D., Shiri, L., Alaei, H., & Naghdi, N.
(2016) Journal of Radiation Research, rrv093.

Differencial Activation of the Dopaminergic Systems in Rat Brain Basal Ganglia by Morphine and Methamphetamine.
Mori, T., Iwase, Y., Saeki, T., Iwata, N., Murata, A., Masukawa, D., & Suzuki, T.
(2016) Neuroscience.

Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
Dang, D. K., Shin, E. J., Nam, Y., Ryoo, S., Jeong, J. H., Jang, C. G., … & Kim, H. C.
(2016) Journal of Neuroinflammation, 13(1), 12.

Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke.
Ishida, A., Isa, K., Umeda, T., Kobayashi, K., Kobayashi, K., Hida, H., & Isa, T.
(2016) The Journal of Neuroscience, 36(2), 455-467.

Contributions of ADP and ATP to the increase in skeletal muscle blood flow after manual acupuncture stimulation in rats.
Nagaoka, S., Shinbara, H., Okubo, M., Kawakita, T., Hino, K., & Sumiya, E.
(2016) Acupuncture in Medicine, acupmed-2015.

2015

Elucidation of the central role of long-chain fatty acids in the palatability of dietary fat by neuroscientific and animal behavioral studies.
Adachi, S.
(2015)

“METHODS AND COMPOSITIONS USING 4-AMINO-2-(2, 6-DIOXO-PIPERIDINE-3-YL)-ISOINDOLINE-1, 3-DIONE FOR TREATMENT OF CANCERS.”
LI, Y., Palmisano, M., Zhou, S., Chen, N., & James, A. J.
(2015)  U.S. Patent No. 20,150,328,199. Washington, DC: U.S. Patent and Trademark Office.

Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats.
Kawaura, K., Ogata, Y., Honda, S., Soeda, F., Shirasaki, T., & Takahama, K.
(2015) Behavioural Brain Research

Ethanol and Acetaldehyde Differentially Alter Extracellular Dopamine and Serotonin in Aldh2-Knockout Mouse Dorsal Striatum: A Reverse Microdialysis Study.
Jamal, M., Ameno, K., Miki, T., Tanaka, N., Ito, A., Ono, J., … & Kinoshita, H.
(2015) NeuroToxicology.

Preventive Effect of 3, 5-dihydroxy-4-methoxybenzyl Alcohol (DHMBA) and Zinc, Components of the Pacific Oyster Crassostrea gigas, on Glutamatergic Neuron Activity in the Hippocampus.
Tamano, H., Shakushi, Y., Watanabe, M., Ohashi, K., Uematsu, C., Otsubo, T., … & Takeda, A.
(2015) The Biological Bulletin, 229(3), 282-288.

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
Bonaventure, P., Shelton, J., Yun, S., Nepomuceno, D., Sutton, S., Aluisio, L., … & Dugovic, C.
(2015) Journal of Pharmacology and Experimental Therapeutics, jpet-115.

Improvement of Cold Injury‐Induced Mouse Brain Edema by Endothelin ETB Antagonists is Accompanied with Decreases in Matrixmetalloproteinase 9 and Vascular Endothelial Growth Factor‐A.
Michinaga, S., Seno, N., Fuka, M., Yamamoto, Y., Minami, S., Kimura, A., … & Koyama, Y.
(2015) European Journal of Neuroscience.

Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Arimon, M., Takeda, S., Post, K. L., Svirsky, S., Hyman, B. T., & Berezovska, O.
(2015) Neurobiology of Disease.

Chewing, Stress-Related Diseases, and Brain Function.
Kubo, K. Y., Chen, H., Liu, J. H., Zhou, X., & Darbin, O.
(2015) BioMed Research International, 2015.

Changes in free amino acid and monoamine concentrations in the chick brain associated with feeding behavior.
Tran, P. V., Chowdhury, V. S., Nagasawa, M., & Furuse, M.
(2015) SpringerPlus 4(1), 252.

Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex.
Ueda, S., Niwa, M., Hioki, H., Sohn, J., Kaneko, T., Sawa, A., & Sakurai, T.
(2015) Molecular Neuropsychiatry,1(2), 94-104.

Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain.
Navratilova, E., Xie, J. Y., Meske, D., Qu, C., Morimura, K., Okun, A., … & Porreca, F.
(2015) The Journal of Neuroscience,, 35(18), 7264-7271.

DSP‐1053, a novel serotonin reuptake inhibitor with 5‐HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats.
Kato, T., Matsumoto, Y., Yamamoto, M., Matsumoto, K., Baba, S., Nakamichi, K., … & Yabuuchi, K.
(2015) Pharmacology Research & Perspectives, 3(3).

2014

 Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy.
Xie, J. Y., Qu, C., Patwardhan, A., Ossipov, M. H., Navratilova, E., Becerra, L., … & Porreca, F.
(2014) PAIN®, 155(8), 1659-1666.

A Food and Administration- approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer’s disease.
Hori Y, Takeda S, Cho H, Wegmann S, Shoup T, Takahashi K, Irima D, Elmaleh D, Hyman B, Hudry E.
(2014) J Biol Chem; 23 1966-78

2018

Validation of an efficient LC-microdialysis method for gemifloxacin quantitation in lung, kidney and liver of rats.
Furness, A. M., Thomas, S., & Lunte, C. E. 10 de Araújo BV, Laureano JV, Grünspan LD, Dalla Costa T, Tasso L.
(3). J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 919–920 (0), 62–66 (2013).

Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis.
Yang, H., Thompson, A. B., McIntosh, B. J., Altieri, S. C., & Andrews, A. M.
(2013). ACS chemical neuroscience, 4(5), 790-798.

Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80

Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.
Navarailova E, Xie J, Okun A, Qu C, Eyde N, Ci S, Ossipov M, King T, Fields H, Porreca F.
(2013) PNAS 109; 50 2079-20713

2012

Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve insury.
Hayashida K, Kimura M, Yoshizumi M,  Hobo S, Obata H, J Eisenach.
(2012) Anesthesiology 117; 389-98

Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Yoshizumi M, Parker R, Esenach J, Hayashida K.
(2012) Anesthesiology 116; 1347-53

2011

Novel microdialysis method to assess meuropeptides and large molecules in free-moiving mouse.
Takeda S, Sato N, Ikimura K, Nishino H, Rkugi H, Morishita R.
(2011) Neuroscience; 186 110-119

2009

[16-1]
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
(2009) Brain Research 1260; 30-37

[15-27]
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T
(2009) British Journal of Pharmacology 156(1):173-180.

2008

[15-16]
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Mitsushima D, Takase K, Funabashi T, Kimura F
(2008) Endocrinology;149(2):802-811. Epub 2007 Oct 25

[15-24]
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M
(2008) Journal of Neuroscience; 28(31):7728-7736

[15-33]
Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
(2008) Toxicology and applied pharmacology Jan 15;226(2):192-198

2007

[15-3]
Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats.
Takase K, Mitsushima D, Funabashi T, Kimura F.
(2007) Brain Research 1154:105-115. Epub 2007 Apr 5

[15-4]
Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups.
Shionoya K, Moriceau S, Bradstock P, Sullivan RM.
(2007) Hormones and Behavior 52(3):391-400. Epub 2007 Jun 29

2006

[14-1]
Ascorbic acid concentration in rabbit vitreous measured by microdialysis with HPLC-electrochemical detection before and after vitreous surgery.
Koide K, Zhang XM, Ohishi K, Usami Y, Hotta Y, Hiramitsu T
(2006) Experimental Eye Research 82(5):868-873

[14-4]
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
(2006) Anesthesiology 104(5):1023-1032

[14-5]
Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats.
Sasaki M, Obata H, Kawahara K, Saito S, Goto F
(2006) Pain 122(1-2):130-136

[13-29]
Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
Dong HL, Fukuda S, Murata E, Higuchi T
(2006) Anesthesiology 104(1):122-133

[13-31]
Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions.
De Leonibus E, Verheij MM, Mele A, Cools A
(2006) European Journal of Neuroscience 23(5):1332-1340

[14-11]
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T
(2006) Journal of Neuroscience 26(2):398-405

[14-20]
Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity.
Takahashi R, Oda Y, Tanaka K, Morishima HO, Inoue K, Asada A.
(2006) Anesthesiology 105(5):984-989

[14-32]
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats.
Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F.
(2006) European Journal of Neuroscience 24(11):3245-3254

2005

[12-16]
Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex.Ago Y, Nakamura S, Baba A, Matsuda T
(2005) Neuropsychopharmacology 30: 43-51

[12-18]
Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.
Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I
(2005) Brain Research 1039(1-2):90-96

[13-16]
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136: 593-599

[13-17]
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats.
Masuda J, Mitsushima D, Funabashi T, Kimura F
(2005) Neuroscience 132: 537-542

[13-21]
Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study.
Yamamoto T, Sakakibara R, Hashimoto K, Nakazawa K, Uchiyama T, Liu Z, Ito T, Hattori T.
(2005) Neuroscience 135: 299-303

[13-34]
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Fusa K, Takahashi I, Watanabe S, Aono Y, Ikeda H, Saigusa T, Nagase H, Suzuki T, Koshikawa N, Cools AR
(2005) Neuroscience 130(3):745-755

[13-35]
Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of dexamphetamine.
Watanabe S, Aono Y, Fusa K, Takada K, Saigusa T, Koshikawa N, Cools AR
(2005) Neuroscience 136(1):251-257

[13-36]
Effects of alpha-methyl-p-tyrosine on extracellular dopamine levels in the nucleus accumbens and the dorsal striatum of freely moving rats.
Watanabe S, Fusa K, Takada K, Aono Y, Saigusa T, Koshikawa N, Cools AR
(2005) Journal of Oral Science 47(4):185-190

[14-12]
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Narita M, Kishimoto Y, Ise Y, Yajima Y, Misawa K, Suzuki T
(2005) Neuropsychopharmacology 30(1):111-118

[14-18]
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.
(2005) British Journal of Pharmacology 145(8):1035-1044

[14-29]
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F.
(2005) Neuroscience 136(2):593-9. Epub 2005 Oct 13

2004

[12-7]
Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
Yamato T, Misumi Y, Yamasaki S, Kino M, Aomine M
(2004) Diabetes, Nutrition & Metabolism 17: 128-136

[12-8]
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.| Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T
(2004) Journal of Neuroscience 24: 2212-2225

[12-9]
The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.
Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto Y, Hashimoto K, Noda Y, Nitta A, Nabeshima T
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 3650-3655

[14-8]
Brain microdialysis study of the effects of hazardous chemicals on the central nervous system 2. Toluene exposure and cerebral acetylcholine.
Honma T, Suda M
(2004) Industrial Health 42(3):336-347

[11-20]
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73

[12-25]
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Okamura N, Hashimoto K, Shimizu E, Kumakiri C, Komatsu N, Iyo M
(2004) Neuropsychopharmacology 29: 544-550

[13-12]
Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J
(2004) British Journal of Pharmacology 142: 414-418

[13-13]
Determination of serotonin, noradrenaline, dopamine and their metabolites in rat brain extracts and microdialysis samples by column liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine.
Yoshitake T, Kehr J, Yoshitake S, Fujino K, Nohta H, Yamaguchi M
(2004) Journal of Chromatography B 807: 177-183

[13-18]
Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Shioda K, Nisijima K, Yoshino T, Kato S
(2004) Progress in Neuro-Psychopharmacology & Biological Psychiatry 28: 633-640

[13-28]
Sexual dimorphism of GABA release in the medial preoptic area and luteinizing hormone release in gonadectomized estrogen-primed rats.
Tin-Tin-Win-Shwe, Mitsushima D, Shinohara K, Kimura F
(2004) Neuroscience 127(1):243-250

[14-21]
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Shen HW, Hagino Y, Kobayashi H, Shinohara-Tanaka K, Ikeda K, Yamamoto H, Yamamoto T, Lesch KP, Murphy DL, Hall FS, Uhl GR, Sora I.
(2004) Neuropsychopharmacology 29(10):1790-1799

2003

[11-1]
Activation of cholinergic and adrenergic receptors increases the concentration of extracellular adenosine in the cerebral cortex of unanesthetized rat.
Bennett HJ, White TD, Semba K
(2003) Neuroscience 117: 119-127

[11-7]
Effects of repetitive transcranial magnetic stimulation on behavioral and neurochemical changes in rats during an elevated plus-maze test.
Kanno M, Matsumoto M, Togashi H, Yoshioka M, Mano Y
(2003) Journal of Neurological Sciences 211: 5-14

 [12-2]
Implication of Rho-associated kinase in the elevation of extracellular dopamine levels and its related behaviors induced by methamphetamine in rats.
Narita M, Takagi M, Aoki K, Kuzumaki N, Suzuki T
(2003) Journal of Neurochemistry 86: 273-282

 [10-16]
Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats.
John J, Wu MF, Kodama T, Siegel JM
(2003) The Journal of Physiology 548(Pt 2): 557-562

 [10-24]
Increase of hippocampal acetylcholine release at the onset of dark phase is suppressed in a mutant mice model of evening-type individuals.
Sei H, Sano A, Oishi K, Fujihara H, Kobayashi H, Ishida N, Morita Y
(2003) Neuroscience 117: 785-789

[10-25]
In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.
Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I
(2003) Alcohol & Alcoholism 38: 197-201

[11-14]
Detection of 3-methoxy-4-hydroxyphenylglycol in rabbit skeletal muscle microdialysate
Tokunaga N, Yamazaki T, Akiyama T, Mori H
(2003) Journal of Chromatography B 798: 163-166

[11-24]
Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse.
Nakahara D, Nakamura M, Iigo M, Okamura H
(2003) Proceedings of the National Academy of Sciences USA (PNAS) 100: 9584-9589

[11-26]
Simultaneous determination of norepinephrine, serotonin, and 5-hydroxyindole-3-acetic acid in microdialysis samples from rat brain by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine.
Yoshitake T, Fujino K, Kehr J, Ishida J, Nohta H, Yamaguchi M
(2003) Analytical Biochemistry 312: 125-33

[12-29]
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
(2003) Psychopharmacology (Berl) 170: 80-88

[13-25]
Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats.
Mitsushima D, Masuda J, Kimura F.
(2003) Neuroendocrinology 78(4):234-240

[13-26]
Sexual dimorphism in the GABAergic control of gonadotropin release in intact rats.
Mitsushima D, Tin-Tin-Win-Shwe, Kimura F
(2003) Neuroscience Research 46(4):399-405

[13-27]
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release.
Mitsushima D, Funabashi T, Shinohara K, Kimura F
(2003) Psychoneuroendocrinology 28(4):574-583

2002

Expression of angiotensin II type 1 (AT1) receptor in the rostral ventrolateral medulla in rats.
Hu, L., Zhu, D. N., Yu, Z., Wang, J. Q., Sun, Z. J., & Yao, T.
(2002) Journal of Applied Physiology, 92(5), 2153-2161.

[10-6]
Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area.
Ozaki S, Narita M, Narita M, Iino M, Sugita J, Matsumura Y, Suzuki T
(2002) Journal of Neurochemistry 82: 1192-1198

[9-13]
Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats.
Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K
(2002) Autonomic Neuroscience 95: 37-42

[9-15]
Effects of moderate hypothermia on in situ cardiac sympathetic nerve endings.
Kitagawa H, Akiyama T, Yamazaki T
(2002) Neurochemistry International 40: 235-242

[9-36]
Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors
Fujino K, Yoshitake T, Inoue O, Ibii N, Kehr J, Ishida J, Nohta H, Yamaguchi M
(2002) Neuroscience Letters 320: 91-95

[10-17]
Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1.
Konishi F, Okada Y, Takaoka M, Gariepy CE, Yanagisawa M, Matsumura Y
(2002) European Journal of Pharmacology 451: 177-184

[10-28]
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359

[10-34]
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y
(2002) Neurochemical Research 27: 497-500

[12-13]
Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Matsuda Y, Hirano H, Watanabe Y
(2002) Brain Research 937: 58-65

 [12-15]
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359

 [13-23]
GABA release in the medial preoptic area of cyclic female rats.|
Mitsushima D, Shwe TT, Funabashi T, Shinohara K, Kimura F
(2002) Neuroscience 113: 109-114

 [13-24]
Profiles of in vivo gamma-aminobutyric acid release in the medial preoptic area of intact and castrated male rats.
Tin-Tin-Win-Shwe, Mitsushima D, Kimura F
(2002) Neuroendocrinology 76(5):290-296

2001

 [9-1]
â-Phenylethlamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D2 receptor mechanism
Kato M, Ishida K, Chuma T, Abe K, Shigenaga T, Taguchi K, Miyake T
(2001) European Journal of Pharmacology 418: 65-71

 [9-3]
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+ – and K+ -evoked serotonin release
Kawata Y, Okada M, Murakami T, Kamata A, Zhu G, Kaneko S
(2001) British Jourmal of Pharmacology 133: 557-567

 [10-1]
Determination of serotonin in microdialysis samples from rat brain by microbore column liquid chromatography with post-column derivatization and fluorescence detection
Yoshitake T, Iizuka R, Kehr J, Nohta H, Ishida J, Yamaguchi M
(2001) Journal of Neuroscience Methods 109: 91-96

 [10-3]
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M
(2001) Brain Research 902: 108-118

 [10-4]
Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Hatip-Al-khati I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara M
(2001) Japanese Journal of Pharmacology 87: 277-287

 [11-2]
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neuroscience Letters 306: 206-208

 [11-5]
Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.
Yoshida Y, Fujiki N, Nakajima T, Ripley B, Matsumura H, Yoneda H, Mignot E, Nishino S
(2001) European Journal of Neuroscience 14: 1075-1081

 [13-5]
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A
(2001) Hypertension 38: 896-901

[13-7]
Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.
Matsuo I, Hirooka Y, Hironaga K, Eshima K, Shigematsu H, Shihara M, Sakai K, Takeshita A
The American Journal of Physiology – Regulatory, Integrative and (2001) Comparative Physiology 280: R1285-1291

 [15-1]
Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats.
Funada M, Hara C.
(2001) Brain Research 901(1-2):247-251

 [8-33]
Adenosine Receptor Subtypes Modulate Two Major Functional Pathways for Hippocampal Serotonin Release.
Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S
(2001) The Journal of Neuroscience 21: 628-640

 [8-34]
Monitering of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely movin rats.
Saigusa T, Fusa K, Okutsu H, Koshikawa N
(2001) Journal of Oral Science 43: 129-134

 [8-36]
Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum.
Yamato H, Kannari K, Shen H, Suda T, Matsunaga M
(2001)Neuropharmacology and Neurotoxicology 12: 1123-1126

 [8-37]
Activationof 5-HT1A but not 5-HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation.
Kannnari K, Yamato H, Shen H, Tomiyama M, Suda T, Matsunaga M
(2001) Journal of Neurochemistry 76: 1346-1353

 [9-10]
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neurosci Letters 306: 206-208

 [9-22]
In vivo assessment of acetylcholine-releasing function at cardiac vagal nerve terminals.
Kawada T, Yamazaki T, Akiyama T, Shishido T, Inagaki M, Uemura K, Miyamoto T, Sugimachi M, Takaki H, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 281: H139-H145

 [9-24]
Effects of ketamine on in vivo cardiac sympathetic nerve endings.
Kitagawa H, Yamazaki T, Akiyama T, Mori H, Sunagawa K
(2001) Journal of Cardiovascular Pharmacology 38 (Suppl. 1): S39-S42

 [12-10]
Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid.
Ueda Y, Doi T, Tokumaru J, Yokoyama H, Nakajima A, Mitsuyama Y, Ohya-Nishiguchi H, Kamada H, Willmore LJ
(2001) Journal of Neurochemistry 76: 892-900

 [12-33]
Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.
Anzawa N, Kushikata T, Ohkawa H, Yoshida H, Kubota T, Matsuki A
(2001) Canadian Journal of Anaesthesia 48: 462-465

 [14-28]
Xenon inhalation increases norepinephrine release from the anterior and posterior hypothalamus in rats.
Yoshida H, Kushikata T, Kubota T, Hirota K, Ishihara H, Matsuki A.
(2001) Canadian Journal of Anesthesia 48:651-655

2000

 [8-1]
Nitric oxide formation in the dog sphincter of Oddi from nitric oxide donors as measured with in vivo microdialysis.
Yamamoto I, Fujiwara M, Kuhara N, Kumano K, Yamada T, Yamamoto H, Fujiwara M
(2000) Alimentary Pharmacology & Therapeutics 14: 1095-1101

 [8-2]
静脈麻酔薬がラット背側海馬の一酸化窒素産生に与える影響(The Influence of Intravenous Anethetics on Nitri Oxide Production in the Rat Dorsal Hippocampus).
白石直之、大井久美子
(2000) 日本歯科麻酔学会雑誌 28: 27-35

 [8-6]
Reserpine Pretreatment Prevents Increase in Extracellular Striatal Dopamine Following L-DOPA Administration in Rats with Nigrostriatal Denervation.
Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M
(2000) Journal of Neurochemistry 74: 263-269

 [9-7]
Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarnic M1 receptor stimulation.
Murakami Y, Ikenoya M, Matsumoto K, Li H, Watanabe H
(2000) Behavioural Brain Research 109: 83-90

 [8-12]
Preferable Monosodium Glutamate and Sodium Chloride Solutions do not Affect Diurnal Norepinephrine Release in the Rat Lateral Hypothalamus.
Smriga M, Torii K
(2000) Nutritional Neuroscience 3: 367-372

 [8-13]
Presynaptic L-type Ca2+ channels on excessive dopamine release from rat caudate putamen.
Okita M, Watanabe Y, Taya K, Utsumi H, Hayashi T
(2000) Physiology & Behavior 68: 641-649

 [8-16]
抹消組織での無麻酔・無拘束マイクロダイアリシス法
倉田知光
(2000) 日薬理誌 116: 181-187

 [9-19]
Chronic adriamycin treatment impairs myocardial interstitial neuronal release of norepinephrine and epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Sunagawa K
(2000) Journal of Cardiovascular Pharmacology 36 (Suppl. 2): S31-S34

 [9-23]
Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K
(2000) Journal of Molecular and Cellular Cardiology 32: 405-414

 [12-35]
Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Ludwig M, Onaka T, Yagi K
(2000) Journal of Neuroendocrinology 12: 477-479

 [13-20]
The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats.
Mishima K, Iwasaki K, Tsukikawa H, Matsumoto Y, Egashira N, Abe K, Egawa T, Fujiwara M.
(2000) Japanese Journal of Pharmacology 84: 163-173

 [14-17]
Activation of peripheral NMDA-nitric oxide cascade in formalin test.
Omote K, Kawamata T, Kawamata M, Nakayama Y, Hazama K, Namiki A.
(2000) Anesthesiology 93(1):173-178

1999

 [8-7]
Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia.
Ohtani N, Sugano T, Ohta M
(1999) Brain Research 842: 6-14

[9-4]
Effect of selegiline on dopamine concentration in the striatum of a primate.
Kaseda S, Nomoto M, Iwata S
(1999) Brain Research 815: 44-50

 [8-26]
セフジトレンピボキシルの脳内移行について
山崎由香子、今井恵子、奈良圭之輔、岩井信市、徳永  晋、小口勝司
(1999) 昭和医学会雑誌 59: 629-634

 [10-13]
Serotonin-mediated increases in the extracellular levels of beta-endorphin in the arcuate nucleus and nucleus accumbens: a microdialysis study.
Zangen A, Nakash R, Yadid G
(1999) Journal of Neurochemistry 73: 2569-2574

1998

 [7-2]
Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis.
Kodama T, Lai YY, Siegel JM
(1998) Brain Research 780: 178-181

 [8-24]
Pharmacokinetics of Topical â-Adrenergic Antagonists in Rabbit Aqueous Humor Evaluated with the Microdialysis Method.
Ohtori R, Sato H, Fukuda S, Ueda T, Koide R, Kanda Y, Kiuchi Y, Oguchi K
(1998) Experimental Eye Research 66: 487-494

 [9-27]
Liquid chromatographic determination of myocardial interstitial epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Inagaki M, Alexander J, Sunagawa K
(1998) Journal of chromatography B 714: 375-378

 [14-35]
Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats.
Sato Y, Horita H, Kurohata T, Adachi H, Tsukamoto T.
(1998) American Journal of Physiology 274(1 Pt 2):R243-R247

1997

 [9-6]
Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats.
Murakami Y, Matsumoto K, Watanabe H
(1997) Biological & Pharmaceutical Bulletin 20: 88-90

 [12-1]
New antioxidant mixture for long term stability of serotonin, dopamine and their metabolites in automated microbore liquid chromatography with dual electrochemical detection.
Thorré K, Pravda M, Sarre S, Ebinger G, Michotte Y
(1997) Journal of Chromatography B, 694: 297-303

 [9-26]
High-performance liquid chromatographic determination of myocardial interstitial dihidroxyphenylglycol.
Takauchi Y, Kitagawa H, Kaeada T, Akiyama T, Yamazaki T
(1997) Journal of Chromatography B 693: 218-221

1995

 [9-28]
Routine high-performance liquid chromatographic determination of myocardial interstitial norepinephrine.
Yamazaki T, Akiyama T, Shindo T
(1995) Journal of Chromatography B 670: 328-331

 [14-31]
Changes of hepatic microsomal oxidative drug metabolizing enzymes in chronic renal failure (CRF) rats by partial nephrectomy.
Uchida N, Kurata N, Shimada K, Nishimura Y, Yasuda K, Hashimoto M, Uchida E, Yasuhara H.
(1995) Japanese Journal of Pharmacology 68(4):431-439

1993

Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
Nakata, N., Kato, H., & Kogure, K.
(1993) Stroke, 24(3), 458-463.

 [14-33]
Increase in serotonin levels in the dog ileum and blood by cisplatin as measured by microdialysis.
Fukui H, Yamamoto M, Ando T, Sasaki S, Sato S.
(1993) Neuropharmacology 32(10):959-968

1991

[14-15]
Pineal microdialysis in freely moving rats.
Azekawa T, Sano A, Sei H, Yamamoto A, Aoi K, Morita Y
(1991) Brain Research Bulletin 26(3):413-417

1990

 [14-14]
Concurrent on-line sampling of melatonin in pineal microdialysates from conscious rat and its analysis by high-performance liquid chromatography with electrochemical detection.
Azekawa T, Sano A, Aoi K, Sei H, Morita Y
(1990) Journal of Chromatography 530(1):47-55

AtmosLM

2018

In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes.
Yamada, K.
(2018). JoVE (Journal of Visualized Experiments), (139), e57869-e57869.

Extracellular α-synuclein levels are regulated by neuronal activity.
Yamada, K., & Iwatsubo, T.
(2018) Molecular neurodegeneration, 13(1), 9.

2017

Tissue distribution of a therapeutic monoclonal antibody determined by large pore microdialysis.
Jadhav, S. B., Khaowroongrueng, V., Fueth, M., Otteneder, M. B., Richter, W., & Derendorf, H.
(2017) Journal of pharmaceutical sciences, 106(9), 2853-2859.

“METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS.”
Davidson, Beverly L., Bradley T. Hyman, and Eloise Hudry.
(2017) Patent 20,170,336,395, issued November 23, 2017.

2016

Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
Kang, S. S., Kurti, A., Baker, K. E., Liu, C. C., Colonna, M., Ulrich, J. D., … & Fryer, J. D.
(2016) Human Molecular Genetics, ddx366.

Extracellular Zn 2+ Is Essential for Amyloid β 1–42-Induced Cognitive Decline in the Normal Brain and Its Rescue.
Takeda, A., Tamano, H., Tempaku, M., Sasaki, M., Uematsu, C., Sato, S., … & Bush, A. I.
(2016) Journal of Neuroscience, 37(30), 7253-7262.

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers.
Xu, H., Gelyana, E., Rajsombath, M., Yang, T., Li, S., & Selkoe, D.
(2016) The Journal of Neuroscience, 36(35), 9041-9056.

2015

Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Yamada, K., Patel, T. K., Hochgräfe, K., Mahan, T. E., Jiang, H., Stewart, F. R., … & Holtzman, D. M.
(2015) Molecular neurodegeneration, 10(1), 1.

A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.
Hori, Y., Takeda, S., Cho, H., Wegmann, S., Shoup, T. M., Takahashi, K., … & Hudry, E.
(2015) Journal of Biological Chemistry, 290(4), 1966-1978.

Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Arimon, M., Takeda, S., Post, K. L., Svirsky, S., Hyman, B. T., & Berezovska, O.
(2015) Neurobiology of disease, 84, 109-119.

2014

Intravenously injected human apolipoprotein AI rapidly enters the central nervous system via the choroid plexus.
Cirrito, J. R.
(2014)

Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus.
Stukas, S., Robert, J., Lee, M., Kulic, I., Carr, M., Tourigny, K., … & Chan, J.
(2014) Journal of the American Heart Association, 3(6), e001156.

Neuronal activity regulates extracellular tau in vivo.
Yamada, K., Holth, J. K., Liao, F., Stewart, F. R., Mahan, T. E., Jiang, H., … & Holtzman, D. M.
(2014) The Journal of experimental medicine, 211(3), 387-393.

Improvement of memory deficits and amyloid-β clearance in aged APP23 mice treated with a combination of anti-amyloid-β antibody and LXR agonist.
Fitz, N. F., Castranio, E. L., Carter, A. Y., Kodali, R., Lefterov, I., & Koldamova, R.
(2014) Journal of Alzheimer’s Disease, 41(2), 535-549.

2013

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567.
Bhattacharya, A., Wang, Q., Ao, H., Shoblock, J. R., Lord, B., Aluisio, L., … & Lovenberg, T. W.
(2013) British journal of pharmacology, 170(3), 624-640

Antisense reduction of tau in adult mice protects against seizures.
DeVos, S. L., Goncharoff, D. K., Chen, G., Kebodeaux, C. S., Yamada, K., Stewart, F. R., … & Bennett, C. F.
(2013) The Journal of Neuroscience, 33(31), 12887-12897.

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis.
Ulrich, J. D., Burchett, J. M., Restivo, J. L., Schuler, D. R., Verghese, P. B., Mahan, T. E., … & Holtzman, D. M.
(2013) Molecular neurodegeneration, 8(1), 1.

Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats.
Ide, S., Hara, T., Ohno, A., Tamano, R., Koseki, K., Naka, T., … & Minami, M.
(2013) The Journal of Neuroscience, 33(14), 5881-5894.

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer’s disease.
Takeda, S., Hashimoto, T., Roe, A. D., Hori, Y., Spires-Jones, T. L., & Hyman, B. T.
(2013) The FASEB Journal, 27(8), 3239-3248.

2012

Selective P2X7 receptor antagonists inhibit Bz-ATP induced IL-1β release in the rat brain.
Aluisio, L., Fraser, I., Lord, B., Bhattacharya, A., Letavic, M., Carruthers, N., … & Bonaventure, P.
(2012) Monitoring Molecules in Neuroscience.

Acethylcholine Analysis

Increased cholinergic response in α-synuclein transgenic mice (h-α-synL62).
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., … & Klein, J.
(2018) ACS Chemical Neuroscience.

Nicotinic receptor-dependent and-independent effects of galantamine, an acetylcholinesterase inhibitor, on the non-neuronal acetylcholine system in C2C12 cells.
Oikawa, S., Mano, A., Iketani, M., & Kakinuma, Y.
(2015) International Immunopharmacology.

Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80

Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve insury.
Hayashida K, Kimura M, Yoshizumi M,  Hobo S, Obata H, J Eisenach.
Anesthesiology,  117;389-98 (2012)

 [15-27]
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T
(2009) British Journal of Pharmacology 156(1):173-180.

[15-16]
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Mitsushima D, Takase K, Funabashi T, Kimura F
(2008) Endocrinology;149(2):802-811. Epub 2007 Oct 25

[14-4]
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
(2006) Anesthesiology 104(5):1023-1032

[13-29]
Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
Dong HL, Fukuda S, Murata E, Higuchi T
(2006) Anesthesiology 104(1):122-133

[12-18]
Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.
Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I
(2005) Brain Research 1039(1-2):90-96

[13-14]
Expression of acetylcholine (ACh) and ACh-synthesizing activity in Archaea.
Yamada T, Fujii T, Kanai T, Amo T, Imanaka T, Nishimasu H, Wakagi T, Shoun H, Kamekura M, Kamagata Y, Kato T, Kawashima K
(2005) Life Sciences 77: 1935-1944

[13-16]
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136: 593-599

[13-17]
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats.
Masuda J, Mitsushima D, Funabashi T, Kimura F
(2005) Neuroscience 132: 537-542

[14-18]
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.
(2005) British Journal of Pharmacology 145(8):1035-1044

[14-29]
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F.
(2005) Neuroscience 136(2):593-9. Epub 2005 Oct 13

[14-8]
Brain microdialysis study of the effects of hazardous chemicals on the central nervous system 2. Toluene exposure and cerebral acetylcholine.
Honma T, Suda M
(2004) Industrial Health 42(3):336-347

[12-25]
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Okamura N, Hashimoto K, Shimizu E, Kumakiri C, Komatsu N, Iyo M
(2004) Neuropsychopharmacology 29: 544-550

[10-24]
Increase of hippocampal acetylcholine release at the onset of dark phase is suppressed in a mutant mice model of evening-type individuals.
Sei H, Sano A, Oishi K, Fujihara H, Kobayashi H, Ishida N, Morita Y
(2003) Neuroscience 117: 785-789

[13-25]
Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats.
Mitsushima D, Masuda J, Kimura F.
(2003) Neuroendocrinology 78(4):234-240

[13-27]
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release.
Mitsushima D, Funabashi T, Shinohara K, Kimura F
(2003) Psychoneuroendocrinology 28(4):574-583

[9-13]
Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats
Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K
(2002) Autonomic Neuroscience 95: 37-42

[12-13]
Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Matsuda Y, Hirano H, Watanabe Y
(2002) Brain Research 937: 58-65

[12-32]
Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate).
Tottori K, Nakai M, Uwahodo Y, Miwa T, Yamada S, Oshiro Y, Kikuchi T, Altar CA
(2002) The Journal of Pharmacology and Experimental Therapeutics 301: 249-257

[9-1]
â-Phenylethlamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D2 receptor mechanism
Kato M, Ishida K, Chuma T, Abe K, Shigenaga T, Taguchi K, Miyake T
(2001) European Journal of Pharmacology 418: 65-71

[10-9]
Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats.
Suzuki S, Yamatoya H, Sakai M, Kataoka A, Furushiro M, Kudo S
(2001) Journal of Nutrition 131:2951-2956

[9-18]
Vagosympathetic interactions in ischemia-induced myocardial norepinephrine and acetylcholine release.
Kawada T, Yamazaki T, Akiyama T, Inagaki M, Shishido T, Zheng C, Yanagiya Y, Sugimachi M, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 280: H216-H221

[9-22]
In vivo assessment of acetylcholine-releasing function at cardiac vagal nerve terminals.
Kawada T, Yamazaki T, Akiyama T, Shishido T, Inagaki M, Uemura K, Miyamoto T, Sugimachi M, Takaki H, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 281: H139-H145

[9-7]
Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarnic M1 receptor stimulation
Murakami Y, Ikenoya M, Matsumoto K, Li H, Watanabe H
(2000) Behavioural Brain Research 109: 83-90

[9-23]
Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K
(2000) Journal of Molecular and Cellular Cardiology 32: 405-414

[13-20]
The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats.
Mishima K, Iwasaki K, Tsukikawa H, Matsumoto Y, Egashira N, Abe K, Egawa T, Fujiwara M.
(2000) Japanese Journal of Pharmacology 84: 163-173

[8-18]
Modification of acetylcholine release by nociceptin in conscious rat striatum
Itoh K, Konya H, Takai E, Masuda H, Nagai K
(1999) Brain Research 845: 242-245

[13-22]
Restriction of environmental space attenuates locomotor activity and hippocampal acetylcholine release in male rats.
Mitsushima D, Yamanoi C, Kimura F
(1998) Brain Research 805: 207-212

[9-6]
Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats
Murakami Y, Matsumoto K, Watanabe H
(1997) Biological & Pharmaceutical Bulletin 20: 88-90

Monoamine (NE, DA and/or 5-HT) Analysis

A Neural Circuit for Gut-Induced Reward.
Han, W., Tellez, L. A., Perkins, M. H., Perez, I. O., Qu, T., Ferreira, J., … & Kaelberer, M. M.
(2018) Cell.

Mesolimbic Dopamine, Its Receptors and Social Learning
Matta, R.
(2018)  (Doctoral dissertation, NOVA Science Publishers).

Novel lacto-peptides in fermented dairy products improve memory function and cognitive decline.
Ano, Y., Ayabe, T., Kutsukake, T., Ohya, R., Takaichi, Y., Uchida, S., … & Nakayama, H.
(2018) Neurobiology of Aging.

Manipulation of dopamine metabolism contributes to attenuating innate high locomotor activity in ICR mice.
Yamaguchi, T., Nagasawa, M., Ikeda, H., Kodaira, M., Minaminaka, K., Chowdhury, V. S., … & Furuse, M.
(2017) Behavioural Brain Research SreeTestContent1.

CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.
Hirose, M., Hasegawa, A., Mochida, K., Matoba, S., Hatanaka, Y., Inoue, K., … & Abe, K.
(2017) Scientific Reports, 7, 42476.

Effects of the 5-HT 6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex.
Mørk, A., Russell, R. V., de Jong, I. E., & Smagin, G.
(2017) European Journal of Pharmacology.

Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors
Tamano, R., Ishida, M., Asaki, T., Hasegawa, M., & Shinohara, S.
(2016)  Neuroscience Letters.

Chewing, Stress-Related Diseases, and Brain Function.
Kubo, K. Y., Chen, H., Liu, J. H., Zhou, X., & Darbin, O.
(2015) BioMed Research International, 2015.

Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain.
Navratilova, E., Xie, J. Y., Meske, D., Qu, C., Morimura, K., Okun, A., … & Porreca, F.
(2015). The Journal of Neuroscience,, 35(18), 7264-7271.

DSP‐1053, a novel serotonin reuptake inhibitor with 5‐HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats.
Kato, T., Matsumoto, Y., Yamamoto, M., Matsumoto, K., Baba, S., Nakamichi, K., … & Yabuuchi, K.
(2015). Pharmacology Research & Perspectives, 3(3).

 [16-1]
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
(2009) Brain Research 1260; 30-37

[15-27]
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T
(2009) British Journal of Pharmacology 156(1):173-180.

[16-3]
Dopamine Release in the Ventromedial Hypothalamus of Growing Chickens Decreases when They are Fed a Lysine Devoid Diet.
Ichijo A, Hayashi N, Fukuoka C, Hu JJ, Yoshizawa F, Sugahara K
(2008) The Journal of Poultry Science 45(4);281-286

[15-24]
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M
(2008) Journal of Neuroscience; 28(31):7728-7736

[15-4]
Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups.
Shionoya K, Moriceau S, Bradstock P, Sullivan RM.
(2007) Hormones and Behavior 52(3):391-400. Epub 2007 Jun 29

[14-5]
Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats.
Sasaki M, Obata H, Kawahara K, Saito S, Goto F
(2006) Pain 122(1-2):130-136

[15-2]
Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum.
Kawasaki T, Ishihara K, Ago Y, Nakamura S, Itoh S, Baba A, Matsuda T.
(2006) European Journal of Pharmacology 542(1-3):92-99. Epub 2006 May 17

[15-5]
Up-regulation of microglial CD11b expression by nitric oxide.
Roy A, Fung YK, Liu X, Pahan K.
(2006) The Journal of Biological Chemistry 281(21):14971-1480. Epub 2006 Mar 20

[13-31]
Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions.
De Leonibus E, Verheij MM, Mele A, Cools A
(2006) European Journal of Neuroscience 23(5):1332-1340

[14-11]
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T
(2006) Journal of Neuroscience 26(2):398-405

[14-32]
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats.
Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F.
(2006) European Journal of Neuroscience 24(11):3245-3254

[12-12]
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice.
Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S
(2005) Proceedings of the National Academy of Sciences USA (PNAS) 102: 4170-4175

[12-16]
Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex.
Ago Y, Nakamura S, Baba A, Matsuda T
(2005) Neuropsychopharmacology 30: 43-51

[12-20]
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.
Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N
(2005) The Journal of Clinical Investigation 115: 102-109

[13-21]
Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study.
Yamamoto T, Sakakibara R, Hashimoto K, Nakazawa K, Uchiyama T, Liu Z, Ito T, Hattori T.
(2005) Neuroscience 135: 299-303

[13-34]
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Fusa K, Takahashi I, Watanabe S, Aono Y, Ikeda H, Saigusa T, Nagase H, Suzuki T, Koshikawa N, Cools AR
(2005) Neuroscience 130(3):745-755

[13-35]
Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of dexamphetamine.
Watanabe S, Aono Y, Fusa K, Takada K, Saigusa T, Koshikawa N, Cools AR
(2005) Neuroscience 136(1):251-257

[13-36]
Effects of alpha-methyl-p-tyrosine on extracellular dopamine levels in the nucleus accumbens and the dorsal striatum of freely moving rats.
Watanabe S, Fusa K, Takada K, Aono Y, Saigusa T, Koshikawa N, Cools AR
(2005) Journal of Oral Science 47(4):185-190

[14-12]
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Narita M, Kishimoto Y, Ise Y, Yajima Y, Misawa K, Suzuki T
(2005) Neuropsychopharmacology 30(1):111-118

[14-18]
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.
(2005) British Journal of Pharmacology 145(8):1035-1044

[12-7]
Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
Yamato T, Misumi Y, Yamasaki S, Kino M, Aomine M
(2004) Diabetes, Nutrition & Metabolism 17: 128-136

[12-8]
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.
Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T
(2004) Journal of Neuroscience 24: 2212-2225

[12-9]
The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.
Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto Y, Hashimoto K, Noda Y, Nitta A, Nabeshima T
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 3650-3655

[11-20]
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73

[11-31]
Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson’s disease.
Kurosaki R, Muramatsu Y, Kato H, Araki T
(2004) Pharmacology, Biochemistry and Behavior 78: 143-153

[12-23]
Serotonin modifies the sensitivity of the male silkmoth to pheromone.
Gatellier L, Nagao T, Kanzaki R
(2004) The Journal of Experimental Biology. 207: 2487-2496

[12-24]
Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL.
Shim JW, Koh HC, Chang MY, Roh E, Choi CY, Oh YJ, Son H, Lee YS, Studer L, Lee SH
(2004) Journal of Neuroscience 24: 843-852

[12-28]
7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.
Matsunaga M, Ukena K, Baulieu EE, Tsutsui K
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 17282-17287

[13-12]
Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J
(2004) British Journal of Pharmacology 142: 414-418

[13-18]
Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Shioda K, Nisijima K, Yoshino T, Kato S
(2004) Progress in Neuro-Psychopharmacology & Biological Psychiatry 28: 633-640

[14-19]
Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation.
Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, Tajima N, Yamada H, Sawada H, Ishikawa H, Mimura T, Kitada M, Suzuki Y, Ide C.
(2004) The Journal of Clinical Investigation 113(12):1701-1710

[14-21]
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Shen HW, Hagino Y, Kobayashi H, Shinohara-Tanaka K, Ikeda K, Yamamoto H, Yamamoto T, Lesch KP, Murphy DL, Hall FS, Uhl GR, Sora I.
(2004) Neuropsychopharmacology 29(10):1790-1799

[11-7]
Effects of repetitive transcranial magnetic stimulation on behavioral and neurochemical changes in rats during an elevated plus-maze test.
Kanno M, Matsumoto M, Togashi H, Yoshioka M, Mano Y
(2003) Journal of Neurological Sciences 211: 5-14

[12-1]
Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.
Narita M, Mizuo K, Mizoguchi H, Sakata M, Narita M, Tseng LF, Suzuki T
(2003) Journal of Neuroscience 23: 1006-1012

[12-2]
Implication of Rho-associated kinase in the elevation of extracellular dopamine levels and its related behaviors induced by methamphetamine in rats.
Narita M, Takagi M, Aoki K, Kuzumaki N, Suzuki T
(2003) Journal of Neurochemistry 86: 273-282

[10-10]
Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.
Narita M, Mizuo K, Mizoguchi H, Sakata M, Narita M, Tseng LF, Suzuki T
(2003) Journal of Neuroscience 23: 1006-1012

[10-11]
An immnosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress.
Fujisaki C, Utsuyama M, Kuroda Y, Watanabe A, Seidler H, Watanabe S, Kitagawa M, Hirokawa K
(2003) Journal of Medical and Dental Sciences 50: 93-100

[10-12]
Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex.
Maeda J, Suhara T, Okauchi T, Semba J
(2003) Neuroscience Letters 336: 171-174

[10-25]
In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.
Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I
(2003) Alcohol & Alcoholism 38: 197-201

[10-27]
Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats.
Mizuma H, Mizutani M, Nozaki S, Iizuka H, Tohyama H, Nishimura N, Watanabe Y, Kohashi R
(2003) Biochemical and Biophysical Research Communications 302: 156-161

[11-11]
Cerebral alterations in a MPTP-mouse model of Parkinson’s disease–an immunocytochemical study.
Muramatsu Y, Kurosaki R, Watanabe H, Michimata M, Matsubara M, Imai Y, Araki T
(2003) Journal of Neural Transmission 110: 1129-1144

[12-29]
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
(2003) Psychopharmacology (Berl) 170: 80-88

[12-30]
An immnosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress.
Fujisaki C, Utsuyama M, Kuroda Y, Watanabe A, Seidler H, Watanabe S, Kitagawa M, Hirokawa K
(2003) Journal of Medical and Dental Sciences 50: 93-100

[10-6]
Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area.
Ozaki S, Narita M, Narita M, Iino M, Sugita J, Matsumura Y, Suzuki T
(2002) Journal of Neurochemistry 82: 1192-1198

[11-9]
Differential roles between dopaminergic and serotonergic systems on motor deficits in mice.
Mizutani H, Muramatsu Y, Araki T
(2002) Brain Pharmacology 1: 253-266

[9-13]
Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats
Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K
(2002) Autonomic Neuroscience 95: 37-42

[9-15]
Effects of moderate hypothermia on in situ cardiac sympathetic nerve endings
Kitagawa H, Akiyama T, Yamazaki T
(2002) Neurochemistry International 40: 235-242

[10-18]
Roles of brain prostaglandin E2 and thromboxane A2 in the activation of the central sympatho-adrenomedullary outflow in rats.
Murakami Y, Okada S, Nishihara M, Yokotani K
(2002) European Journal of Pharmacology 452: 289-294

[10-28]
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359

[12-15]
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359

[9-3]
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+ – and K+ -evoked serotonin release
Kawata Y, Okada M, Murakami T, Kamata A, Zhu G, Kaneko S
(2001) British Jourmal of Pharmacology 133: 557-567

[10-1]
Determination of serotonin in microdialysis samples from rat brain by microbore column liquid chromatography with post-column derivatization and fluorescence detection
Yoshitake T, Iizuka R, Kehr J, Nohta H, Ishida J, Yamaguchi M
(2001) Journal of Neuroscience Methods 109: 91-96

[10-3]
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M
(2001) Brain Research 902: 108-118

[10-4]
Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Hatip-Al-khati I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara M
(2001) Japanese Journal of Pharmacology 87: 277-287

[15-1]
Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats.
Funada M, Hara C.
(2001) Brain Research 901(1-2):247-251

[8-33]
Adenosine Receptor Subtypes Modulate Two Major Functional Pathways for Hippocampal Serotonin Release.
Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S
(2001) The Journal of Neuroscience 21: 628-640

[8-34]
Monitering of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely movin rats.
Saigusa T, Fusa K, Okutsu H, Koshikawa N
(2001) Journal of Oral Science 43: 129-134

[8-36]
Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum
Yamato H, Kannari K, Shen H, Suda T, Matsunaga M
(2001) Neuropharmacology and Neurotoxicology 12: 1123-1126

[8-37]
Activationof 5-HT1A but not 5-HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation
Kannnari K, Yamato H, Shen H, Tomiyama M, Suda T, Matsunaga M
(2001) Journal of Neurochemistry 76: 1346-1353

[9-14]
Myocardial interstitial norepinephrine and dihydroxyphenylglycol levels during ischemia and reperfusion
Akiyama T, Yamazaki T
(2001) Cardiovasclar Research 49: 78-85

[9-18]
Vagosympathetic interactions in ischemia-induced myocardial norepinephrine and acetylcholine release
Kawada T, Yamazaki T, Akiyama T, Inagaki M, Shishido T, Zheng C, Yanagiya Y, Sugimachi M, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 280: H216-H221

[9-24]
Effects of ketamine on in vivo cardiac sympathetic nerve endings
Kitagawa H, Yamazaki T, Akiyama T, Mori H, Sunagawa K
(2001) Journal of Cardiovascular Pharmacology 38 (Suppl. 1): S39-S42

[9-32]
Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs
Yamasaki T, Tamai I, Matsumura Y
American Journal of Physiology – Regulatory, Integrative and Comparative (2001) Physiology 280: R1450-R1456

[9-33]
Effects of bradykinin on renal nerve stimulation-induced antidiuresis and norepinephrine overflow in anesthetized dogs
Tadano K, Yamasaki T, Matsumura Y
(2001) Jounal of Cardiovascular Pharmacology 37: 461-470

[10-21]
Role of brain arachidonic acid cascade on central CRF1 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
Yokotani K, Murakami Y, Okada S, Hirata M
(2001) European Journal of Pharmacology 419: 183-189

[11-10]
Riluzole protects against MPTP-induced dopamine and DOPAC depletion in mice.
Kumagai T, Ido T, Araki T, Matsubara m, Imai Y
(2001) Biogenic Amines 16: 157-172

[11-12]
Neuroprotective effect of riluzole in MPTP-treated mice.
Araki T, Kumagai T, Tanaka K, Matsubara M, Kato H, Itoyama Y, Imai Y
(2001) Brain Research 918: 176-181

[12-33]
Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.
Anzawa N, Kushikata T, Ohkawa H, Yoshida H, Kubota T, Matsuki A
(2001) Canadian Journal of Anaesthesia 48: 462-465

[14-28]
Xenon inhalation increases norepinephrine release from the anterior and posterior hypothalamus in rats.
Yoshida H, Kushikata T, Kubota T, Hirota K, Ishihara H, Matsuki A.
(2001) Canadian Journal of Anesthesia 48:651-655

[8-6]
Reserpine Pretreatment Prevents Increase in Extracellular Striatal Dopamine Following L-DOPA Administration in Rats with Nigrostriatal Denervation
Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M
(2000) Journal of Neurochemistry 74: 263-269

[11-3]
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.
Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, Nishikawa SI, Sasai Y
(2000) Neuron 28: 31-40

[8-12]
Preferable Monosodium Glutamate and Sodium Chloride Solutions do not Affect Diurnal Norepinephrine Release in the Rat Lateral Hypothalamus
Smriga M, Torii K
(2000) Nutritional Neuroscience 3: 367-372

[8-13]
Presynaptic L-type Ca2+ channels on excessive dopamine release from rat caudate putamen
Okita M, Watanabe Y, Taya K, Utsumi H, Hayashi T
(2000) Physiology & Behavior 68: 641-649

[8-19]
Selective Corticotropin-Releasing Factor Type 1 Receptor Antagonist Blocks Conditioned Fear-Induced Release of Noradrenaline in the Hypothalamic Paraventricular Nucleus of Rats
Otagiri A, Wakabayashi I, Shibasaki T
(2000) Journal of Neuroendocrinology 12: 1022-1026

[9-19]
Chronic adriamycin treatment impairs myocardial interstitial neuronal release of norepinephrine and epinephrine
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Sunagawa K
(2000) Journal of Cardiovascular Pharmacology 36 (Suppl. 2): S31-S34

[9-23]
Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K
(2000) Journal of Molecular and Cellular Cardiology 32: 405-414

[10-19]
Brain phospholipase A(2)-arachidonic acid cascade is involved in the activation of central sympatho-adrenomedullary outflow in rats.
Yokotani K, Wang M, Murakami Y, Okada S, Hirata M
(2000) European Journal of Pharmacology 398: 341-347

[12-35]
Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Ludwig M, Onaka T, Yagi K
(2000) Journal of Neuroendocrinology 12: 477-479

[8-7]
Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia
Ohtani N, Sugano T, Ohta M
(1999) Brain Research 842: 6-14

[9-4]
Effect of selegiline on dopamine concentration in the striatum of a primate
Kaseda S, Nomoto M, Iwata S
(1999) Brain Research 815: 44-50

[10-13]
Serotonin-mediated increases in the extracellular levels of beta-endorphin in the arcuate nucleus and nucleus accumbens: a microdialysis study.
Zangen A, Nakash R, Yadid G
(1999) Journal of Neurochemistry 73: 2569-2574

[12-1]
New antioxidant mixture for long term stability of serotonin, dopamine and their metabolites in automated microbore liquid chromatography with dual electrochemical detection
Thorré K, Pravda M, Sarre S, Ebinger G, Michotte Y
(1997) Journal of Chromatography B, 694: 297-303

[9-28]
Routine high-performance liquid chromatographic determination of myocardial interstitial norepinephrine
Yamazaki T, Akiyama T, Shindo T
(1995) Journal of Chromatography B 670: 328-331

[10-20]
Elevation of plasma noradrenaline levels in urethane-anaesthetized rats by activation of central prostanoid EP3 receptors.
Yokotani K, Nishihara M, Murakami Y, Hasegawa T, Okuma Y, Osumi Y
(1995) British Journal of Pharmacology 115: 672-676

Amino Acids

Relief of hypersensivitity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80

Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Yoshizumi M, Parker R, Esenach J, Hayashida K.
(2012) Anesthesiology 116:1347-53

Glutamate Enzymatic Assay

[12-12]
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice.
Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S
(2005) Proceedings of the National Academy of Sciences USA (PNAS) 102: 4170-4175

[13-18]
Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Shioda K, Nisijima K, Yoshino T, Kato S
(2004) Progress in Neuro-Psychopharmacology & Biological Psychiatry 28: 633-640

[12-3]
Reversible suppression of glutamatergic neurotransmission of cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain.
Yamamoto M, Wada N, Kitabatake Y, Watanabe D, Anzai M, Yokoyama M, Teranishi Y, Nakanishi S
(2003) Journal of Neuroscience 23: 6759-6767

[11-28]
Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures.
Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Inoue K
(2003) Proceedings of the National Academy of Sciences USA (PNAS) 100: 11023-11028

Glutathione

[15-31]
Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase.
Haramaki N, Ikeda H, Takenaka K, Katoh A, Sugano R, Yamagishi S, Matsuoka H, Imaizumi T
(2007) Arteriosclerosis, Thrombosis, and Vascular Biology 27(6):1471-147.

[12-21]
Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers.
Morita H, Ikeda H, Haramaki N, Eguchi H, Imaizumi T
(2005)Journal of the American College of Cardiology 45: 589-594

[10-22]
Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay.
Hiraku Y, Murata M, Kawanishi S
(2002) Biochimica et Biophysica Acta 1570: 47-52

[10-34]
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y
(2002) Neurochemical Research 27: 497-500

[12-31]
Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide.
Mizutani H, Tada-Oikawa S, Hiraku Y, Oikawa S, Kojima M, Kawanishi S
(2002) Journal of Biological Chemistry 277: 30684-30689

[12-34]
Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione.
Haramaki N, Ikeda H, Takajo Y, Katoh A, Kanaya S, Shintani S, Haramaki R, Murohara T, Imaizumi T
(2001) Arteriosclerosis, Thrombosis, and Vascular Biology 21: 1852-1856

8-OH-dG Analysis

[13-6]
Normalization of elevated hepatic 8-hydroxy-2′-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet.
Kato J, Kobune M, Nakamura T, Kuroiwa G, Takada K, Takimoto R, Sato Y, Fujikawa K, Takahashi M, Takayama T, Ikeda T, Niitsu Y
(2001) Cancer Research 61: 8697-8702

[8-21]
Fatal Severe Vasospasm Due to Rewarming Following Hypothermia -Case Report-
Jimbo H, Dohi K, Nakamura Y, Izumiyama H, Ikeda Y, Matsumoto K, Kushima M, Takaki A
(2000) Neurologia medico-chirurgica 40: 463-466

3-Nitrotyrosine

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers.
Xu, H., Gelyana, E., Rajsombath, M., Yang, T., Li, S., & Selkoe, D.
(2016) The Journal of Neuroscience, 36(35), 9041-9056.

Seed‐competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer’s disease mouse model and human patients.
Takeda, S., Commins, C., DeVos, S. L., Nobuhara, C. K., Wegmann, S., Roe, A. D., … & Lipsanopoulos, T.
(2016) Annals of Neurology.

Central apelin mediates stress-induced gastrointestinal motor dysfunction in rats
Bülbül, M., Izgut-Uysal, V. N., Sinen, O., Birsen, İ., & Tanrıöver, G.
(2015) American Journal of Physiology-Gastrointestinal and Liver Physiology, ajpgi-00145.

METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS.
Davidson, B. L., & Hyman, B. T.
(2015) U.S. Patent No. 20,150,183,850.Washington, DC: U.S. Patent and Trademark Office.

Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Davidson, B. L., & Hyman, B. T.
(2015) Neurobiology of Disease.

A Food and Administration- approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer’s disease.
Hori Y, Takeda S, Cho H, Wegmann S, Shoup T, Takahashi K, Irima D, Elmaleh D, Hyman B, Hudry E.
(2014) J Biol Chem; 23 1966-78

Improvement of memory deficits and Aβ clearance in aged APP23 mice treated with a combination of anti-Aβ antibody and LXR agonist.
Fitz, N. F., Castranio, E. L., Carter, A. Y., Kodali, R., Lefterov, I., & Koldamova, R.
(2014) Journal of Alzheimer’s disease: JAD,41(2), 535.

Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2.
Takamatsu, K., Ikeda, T., Haruta, M., Matsumura, K., Ogi, Y., Nakagata, N., … & Senju, S.
(2014) Stem cell research,13(3), 442-453.

Antisense reduction of tau in adult mice protects against seizures.
DeVos, S. L., Goncharoff, D. K., Chen, G., Kebodeaux, C. S., Yamada, K., Stewart, F. R., … & Miller, T. M.
(2013) The Journal of Neuroscience,33(31), 12887-12897.

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis.
Ulrich, J. D., Burchett, J. M., Restivo, J. L., Schuler, D. R., Verghese, P. B., Mahan, T. E., … & Holtzman, D. M.
(2013) Molecular neurodegeneration,8(1), 1-7.

Novel microdialysis method to assess meuropeptides and large molecules in free-moiving mouse.
Takeda S, Sato N, Ikimura K, Nishino H, Rkugi H, Morishita R.
(2011) Neuroscience; 186 110-119

[14-24]
Disposition of protein-bound 3-nitrotyrosine in rat plasma analysed by a novel protocol for HPLC-ECD.
Hitomi YH, Okuda J, Nishino H, Kambayashi Y, Hibino Y, Takemoto K, Takigawa T, Ohno H, Taniguchi N, Ogino K.
(2007) Journal of Biochemistry (Tokyo) 141(4):495-502. Epub 2007 Jan 29

[12-27]
Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice.
Okamoto T, Gohil K, Finkelstein EI, Bove P, Akaike T, van der Vliet A
(2004) American Journal of Physiology – Lung Cellular and Molecular Physiology 286: L198-209

[9-12]
Determination of nitrotyrosine by HPLC-ECD and its application.
Ishida N, Hasegawa T, Mukai K, Watanabe M, Nishino H
(2002) Journal of Veterinary Medical Science 64: 401-404